INTERNATIONAL WORKSHOP ON CHROMOSOME 21

21 号染色体国际研讨会

• 批准号: 3435517
• 负责人: STYLIANOS E ANTONARAKIS
• 金额: $ 2.83万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-04-06 至 1993-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3435517
• 关键词: artificial chromosomes; chromosomes; genetic mapping; human genetic material tag; linkage mapping; travel; workshop

Funds are requested to support the 3rd international workshop to determine the status of the genetic and physical maps of human chromosome 21 (HC21). (The first workshop was held in Bethesda, MD and organized by Dr. D. Cox; the 2nd workshop was held in Denver, CO and was organized by Dr. D. Patterson.) The workshop entitled "Mapping Chromosome 21: Present Status and Future Strategies" will be held in Baltimore in April 1992 for 2 days and will include 46 scientists from the United States and 26 scientists from abroad. The primary focus of the meeting will be to assess progress on the physical and genetic map of HC21 since the 1991 workshop and the status of cDNA mapping on HC21. An important aspect will be to assess the progress of the Joint YAC Screening Effort which was established at the 1990 workshop and to make any adjustments felt necessary in that screening effort. An attempt will be made to determine the feasibility and desirability of attempting to completely close the physical map of HC21. Assessment will be made of the progress toward a high resolution genetic linkage map using all available published and unpublished data so that strategies can be devised to enhance completion of this objective, if necessary. The conference will assess the status of the comparative mouse map of regions of the mouse genome homologous to HC21, assess available data on isolation of gene sequences from HC21, and determine the advisability of undertaking a major effort toward isolating a large number of HC21 specific gene sequences.

要求提供资金，以支持第三次国际研讨会， 人类21号染色体（HC 21）的遗传和物理图谱的状态。 (The第一次研讨会在马里兰州贝塞斯达举行，由D.考克斯; 第二次研讨会在科罗拉多州丹佛市举行，由D. 帕特森。） 题为“绘制21号染色体：现状”的讲习班 和未来战略”将于1992年4月在巴尔的摩举行，为期两天 将包括46名来自美国的科学家和26名来自 从国外 会议的主要重点将是评估进展情况 自1991年研讨会以来， HC 21上cDNA定位状态。 一个重要方面是评估 青年咨询委员会联合筛选工作的进展情况， 1990年讲习班，并在筛选过程中作出任何必要的调整 努力 将尝试确定可行性， 试图完全关闭HC 21的物理地图的可取性。 将对高分辨率遗传学的进展进行评估， 使用所有可用的已发布和未发布的数据， 可以制定战略，以促进完成这一目标，如果 必要 会议将评估比较小鼠的状况 与HC 21同源的小鼠基因组区域图，评估可用的 从HC 21分离基因序列的数据，并确定 采取重大措施隔离大量 HC 21基因序列。