XENON NMR SPECTROSCOPY--MECHANISM OF GENERAL ANESTHESIA

氙核磁共振波谱--全身麻醉的机制

• 批准号: 3438664
• 负责人: KENNETH L WILLIAMSON
• 金额: $ 8.05万
• 依托单位: MOUNT HOLYOKE COLLEGE
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-08-01 至 1991-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3438664
• 关键词: chemical structure; liposomes; micelles; nuclear magnetic resonance spectroscopy; phospholipids; proteins; water solution; xenon

It is proposed to develop and test the xenon atom as a probe of biological microstructure using nuclear magnetic resonance (NMR) spectroscopy. Systems to be investigated might include simple aqueous systems, micellar solutions, vesicles, multilamellar liposomes, and proteins. The techniques to be used for this investigation include xenon solubility, xenon NMR chemical shift measurements, temperature studies, solvent and paramagnetic ion effects on the Xe chemical shift, 129Xe and 131Xe relaxation time studies, nuclear Overhauser effect measurements, and chemical shift measurements made at high (ca.100 atm) Xe and hydrostatic pressures. The expectation is to show that this small, inert atom is a unique probe capable of reporting structural information on biological microstructures difficult to obtain by other means. In this study information pertinent to the mechanism by which xenon functions as a general anesthetic may be found.

提出了开发和测试氙原子作为一种探针