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AEROBIC TRAINING AND BONE MINERAL DENSITY IN WOMEN

女性有氧训练和骨矿物质密度

基本信息

批准号：
3436388
负责人：
ANATOLE Daniel MARTIN
金额：
$ 6.9万
依托单位：
UNIVERSITY OF FLORIDA
依托单位国家：
美国
项目类别：
财政年份：
1988
资助国家：
美国
起止时间：
1988-06-01 至 1990-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3436388
关键词：
bone density bone fracture calcium metabolism densitometry dietary calcium dietary supplements disease /disorder prevention /control exercise female human subject osteoporosis postmenopause

项目摘要

Osteoporosis affects approximately 25% of women over the age of 60, with an estimated 540,000 women experiencing non-traumatic vertebral fractures every year. Currently, there is no effective treatment for vertebral crush fractures, highlighting the importance of preventing this condition. Moderate exercise is frequently mentioned as a means of maintaining or even increasing bone mineral density (BMD) and possibly preventing the development of osteoporotic fractures. Unfortunately, this recommendation is based on a limited number of studies that have measured the effects of various exercise training program on BMD in post menopausal women (PMW). Furthermore, the minimal amount of exercise needed to increase BMD is unknown. Before individuals at risk for developing osteoporosis can be counseled on means to reduce their risk, quantified information on the effectiveness of various prophylactic measures is needed. The current study proposes to examine two questions: 1) what is the dose-response relationship between aerobic exercise and BMD in naturally PMW and, 2) what are the effects of aerobic exercise on exercise capacity in naturally PMW? Sedentary, naturally PMW will be recruited and screened for the presence of conditions that might influence calcium metabolism or invalidate the bone densitometry test. Sixty subjects free from these conditions will then be randomly assigned to either a non-exercising control group or to one of two exercising groups (20 subjects per group) and given 750 mg/day of elemental calcium. The exercise groups will train three times per week for one year at 70-85% of their maximal heart rate on motorized treadmills for either 30 or 45 minutes per session. BMD of the lumbar vertebrae (L1-L4) and radius will be measured with dual photon absorptiometry and single photon absorptiometry, respectively. BMD will be evaluated at baseline and following 6 and 12 months of training. Maximal oxygen uptake will be measured at baseline and following 3, 6 and 12 months of training. This study will expand upon the existing literature by evaluating a homogenous sample of naturally PMW, free of conditions that might influence calcium metabolism or invalidate DPA bone densitometry and provide information on two questions: 1) what is the dose response relationship between aerobic exercise and BMD in naturally PMW and, 2) what are the effects of long-term aerobic exercise training on exercise tolerance in sedentary, naturally PMW?

骨质疏松症影响大约25%的年龄以上的妇女 60，估计有540，000名妇女经历了非创伤性每年都有脊椎骨折目前，没有有效的脊椎粉碎性骨折的治疗，强调预防这种情况的重要性。适度的运动是经常被提及作为维持甚至增加的手段骨矿物质密度（BMD），并可能防止发展成骨质疏松性骨折。可惜这建议是基于数量有限的研究，测量了各种运动训练计划对绝经后妇女的BMD（PMW）。而且增加BMD所需的最小运动量尚不清楚。在有患骨质疏松症风险的人可以就减少风险的手段提供咨询，需要各种预防措施的有效性。的目前的研究提出了两个问题：1）什么是有氧运动与骨密度的剂量-反应关系自然PMW和，2）有氧运动的影响是什么？运动能力自然PMW？久坐不动，自然PMW 将被招募和筛选的条件，可能会影响钙代谢或使骨骼失效密度测定测试。 60名无上述情况的受试者将然后被随机分配到非锻炼对照组，组或两个运动组之一（每组20名受试者）并给予750毫克/天的元素钙。锻炼组将每周训练三次，为期一年，在30或45分钟内，电动跑步机的最大心率每节课分钟。腰椎（L1-L4）的BMD，将使用双光子吸收法测量半径，单光子吸收法。 BMD将是在基线以及6个月和12个月的培训后进行评估。将在基线和以下时间测量最大摄氧量 3、6、12个月的培训。这项研究将扩大在现有文献通过评估同质样本，天然PMW，无可能影响钙的条件代谢或使DPA骨密度测定无效，并提供关于两个问题的信息：1）剂量反应是什么有氧运动与自然绝经后妇女骨密度的关系 2）长期有氧运动的效果是什么训练运动耐力久坐，自然PMW？