GENETICS LABORATORY FOR TYPING PRIMATES

恒河猴是人类生物学和 行为，因为它们与人类关系密切 因为现在有大量已建立的基因 标记和越来越多的血统殖民地。 此应用程序是对服务的基本支持的坦率请求 将作为基因研究资源的实验室 猕猴(猕猴)的分型。这个实验室将 配备20余种红细胞抗原(血液)分型 两种血清蛋白(转铁蛋白和补体C3)和 至少四种同工酶(多种分子形式的酶)。它 将能够为超过18种不同的基因提供分型 这些系统加在一起可以定义超过一万亿 在这个物种中有不同的表型。这些遗传标记是 维护准确的谱系记录的基本工具；没有 他们不可能解决有争议的亲子关系 经常出现在繁衍的群体中。此外，这些 将使用标记来保持育种记录的准确性 通过检测由于身份错误而导致的错误、不适当 转录，婴儿交换或意想不到的配对。最后， 这些遗传标记将被用来监测近亲繁殖和损失。 基因变异性可能会威胁到 恒河猴种群。

Rhesus monkeys are excellent models of human biology and behavior because of their close relationship to humans and because there is now a large number of established genetic markers and an increasing availability of pedigreed colonies. This application is a frank request for base support of a service laboratory which will serve as a research resource for genetic typing of rhesus monkeys (Macaca mulatta). This laboratory will be equipped to type for more than 20 erythrocyte antigens (blood groups), two serum proteins (transferrins and C3 complement) and at least four isozymes (multiple molecular forms of enzymes). It will be able to provide typing for more that 18 different genetic systems which taken together can define more than a trillion different phenotypes in this species. These genetic markers are essential tools for maintaining accurate pedigree records; without them it would be impossible to resolve disputed paternity which is encountered often in breeding colonies. In addition, these markers will be used to maintain the accuracy of breeding records by detecting errors resulting from mistaken identity, improper transcriptions, infant switches or unexpected matings. Finally, these genetic markers will be used to monitor inbreeding and loss of genetic variability which can threaten the very survival of rhesus populations.