GENETICS LABORATORY FOR TYPING PRIMATES

灵长类动物打字遗传学实验室

• 批准号: 3450967
• 负责人: WILLIAM H STONE
• 金额: $ 5.99万
• 依托单位: TRINITY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-06-01 至 1991-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3450967
• 关键词: Macaca mulatta; animal population genetics; animal population study; blood group antigens; blood groups; erythrocytes; gene expression; gene frequency; genetic mapping; genetic markers; genetic strain; genotype; inbreeding; isozymes

Rhesus monkeys are excellent models of human biology and behavior because of their close relationship to humans and because there is now a large number of established genetic markers and an increasing availability of pedigreed colonies. This application is a frank request for base support of a service laboratory which will serve as a research resource for genetic typing of rhesus monkeys (Macaca mulatta). This laboratory will be equipped to type for more than 20 erythrocyte antigens (blood groups), two serum proteins (transferrins and C3 complement) and at least four isozymes (multiple molecular forms of enzymes). It will be able to provide typing for more that 18 different genetic systems which taken together can define more than a trillion different phenotypes in this species. These genetic markers are essential tools for maintaining accurate pedigree records; without them it would be impossible to resolve disputed paternity which is encountered often in breeding colonies. In addition, these markers will be used to maintain the accuracy of breeding records by detecting errors resulting from mistaken identity, improper transcriptions, infant switches or unexpected matings. Finally, these genetic markers will be used to monitor inbreeding and loss of genetic variability which can threaten the very survival of rhesus populations.

恒河猴是人类生物学的优秀模型， 因为它们与人类的密切关系， 因为现在有大量的基因 标记和越来越多的纯种殖民地的可用性。 此应用程序是一个坦率的要求基地支持的服务 实验室将作为遗传学研究资源， 恒河猴（Macaca mulatta）。 该实验室将 配备有超过20种红细胞抗原（血液）的类型 两种血清蛋白（转铁蛋白和C3补体）， 至少四种同工酶（酶的多种分子形式）。 它 将能够提供18种不同的基因型， 这些系统加在一起可以定义超过一万亿个 在这个物种中有不同的表型。 这些遗传标记是 保持准确的系谱记录的必要工具;没有 他们不可能解决有争议的亲子关系， 在繁殖地经常遇到。 另外这些 标记将用于保持育种记录的准确性 通过检测由错误的身份、不适当的 婴儿交换或意外交配。 最后， 这些遗传标记将用于监测近亲繁殖和损失 基因变异的威胁， 恒河猴种群