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SynbiCITE - an Imperial College led Innovation and Knowledge Centre (IKC) in Synthetic Biology

SynbiCITE - 帝国理工学院领导的合成生物学创新和知识中心 (IKC)

基本信息

批准号：
EP/L011573/1
负责人：
Richard Kitney
金额：
$ 646.55万
依托单位：
Imperial College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2013
资助国家：
英国
起止时间：
2013 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FL011573%2F1
关键词：
SynbiCITE Imperial College led Innovation

项目摘要

Synthetic biology is a new and exciting research field that brings together biological scientists and engineers with the aim of developing new ways to build and alter biological systems and cells. Biological cells can perform a vast array of activities driven by instructions, which are encoded by DNA. This DNA makes up the cells genome, which act as a blueprint for different types of cells and is composed of four complementary chemical building blocks called nucleotides (G, C, A and T) linked together in a sequence. The beauty of DNA is that these building blocks pair up specifically (G-C and A-T) thus the DNA template can be easily copied and replicated. The instructions encoded in DNA are translated specifically into an array of large molecules called proteins which act as the engines of the cell performing all the necessary functions for cells to live divide and grow e.g. the conversion of food sources like sugar into energy. Over the last 20 years advances in our ability to 'read' DNA has resulted in the complete genome sequences of a variety of living organisms including humans. These sequences encode the basic instruction parts for that specific organism. More recent advances in the chemical synthesis of DNA, has resulted in our increasing ability to 'write' DNA. Synthetic biology therefore aims to provide an engineering framework that allows researchers to design and write DNA tailored to specific applications such that these new synthetic DNA sequences can be placed in cells to perform specific human defined functions. One overarching aim at present is to develop a series of foundational techniques in synthetic biology such as assembling complex DNA components, characterising the instruction parts in detail and computer modelling of more complex DNA designs such that these can be applied to different applications. One overarching concept for synthetic biology is the development of standard DNA components that can used in an engineering 'design, build and test' cycle to create new biological systems and cells that display defined and predictable functions.Many researchers, policy makes and national governments anticipate that synthetic biology will provide a range of benefits to society in different industrial sectors including human health; agriculture and food production; environmental protection and remediation; bioenergy and chemical. To accelerate the translation of synthetic biology technology to new applications we propose to establish a national UK Innovation and Knowledge Centre in synthetic biology with three main objectives:(1) To act as an industrial translation engine which translates university and industry based research in synthetic biology into industrial process and products(2) To be an effective vehicle for the support of small to medium sized UK companies including Start-ups in synthetic biology(3) To actively engage in open dialogue with the public and other stakeholders focusing on the risks and benefits of synthetic biology technologiesThe IKC aims to place the UK as one of the World's leaders in translating academic synthetic biology research into new products and process but under the framework of 'Responsible Innovation' where the public worth and potential risks of specific applications are considered before such applications are implemented or even reach the market. Such an approach will establish new sustainable synthetic biology industries in the UK, allow other non-UK companies to invest in the UK and develop a skilled workforce in synthetic biology all of which will ultimately lead to new economic growth.

合成生物学是一个新的令人兴奋的研究领域，它汇集了生物科学家和工程师，旨在开发新的方法来构建和改变生物系统和细胞。生物细胞可以执行由DNA编码的指令驱动的大量活动。这些DNA构成了细胞基因组，充当了不同类型细胞的蓝图，由四种互补的化学构建块组成，称为核苷酸（G， C， a和T）按顺序连接在一起。DNA的美妙之处在于这些构建块（G-C和A-T）特别配对，因此DNA模板可以很容易地复制和复制。编码在DNA中的指令被专门翻译成一系列被称为蛋白质的大分子，这些大分子充当细胞的引擎，执行细胞生存、分裂和生长所需的所有功能，例如将糖等食物来源转化为能量。在过去的20年里，我们“阅读”DNA的能力取得了进步，包括人类在内的各种生物体的完整基因组序列已经得到了确定。这些序列编码了特定生物体的基本指令部分。在DNA化学合成方面的最新进展，使我们“书写”DNA的能力不断增强。因此，合成生物学旨在提供一个工程框架，使研究人员能够设计和编写适合特定应用的DNA，这样这些新的合成DNA序列就可以放入细胞中执行特定的人类定义功能。目前的一个首要目标是开发一系列合成生物学的基础技术，如组装复杂的DNA成分，详细描述指令部分，以及更复杂的DNA设计的计算机建模，以便这些技术可以应用于不同的应用。合成生物学的一个重要概念是开发标准的DNA成分，这些成分可以在工程“设计、构建和测试”周期中使用，以创造新的生物系统和细胞，这些生物系统和细胞显示出明确和可预测的功能。许多研究人员、决策者和国家政府预计，合成生物学将在不同的工业部门，包括人类健康，为社会带来一系列惠益；农业和粮食生产；环境保护与整治；生物能源和化学。为了加速将合成生物学技术转化为新的应用，我们建议建立一个英国国家合成生物学创新和知识中心，其主要目标有三个：(1)作为一个工业翻译引擎，将大学和工业合成生物学研究转化为工业过程和产品(2)成为支持中小型英国公司（包括合成生物学初创企业）的有效工具(3)积极与公众和其他利益相关者进行公开对话，重点关注合成生物学技术的风险和收益IKC的目标是使英国成为世界上将学术合成生物学研究转化为新产品和新工艺的领导者之一，但在“负责任的创新”的框架下，在实施或甚至进入市场之前，要考虑特定应用的公众价值和潜在风险。这种方法将在英国建立新的可持续合成生物学产业，允许其他非英国公司在英国投资，并培养合成生物学领域的熟练劳动力，所有这些最终将导致新的经济增长。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Tiny but mighty

微小但强大

DOI：
10.1016/s0262-4079(16)30547-4
发表时间：
2016
期刊：
New Scientist
影响因子：
1.7
作者：
Coghlan A
通讯作者：
Coghlan A

The Sixth International Meeting on Synthetic Biology (SB6.0) special issue editorial.

第六届国际合成生物学会议（SB6.0）特刊社论。

DOI：
10.1021/sb500085b
发表时间：
2014
期刊：
ACS synthetic biology
影响因子：
4.7
作者：
Cai Y
通讯作者：
Cai Y

One-pot DNA construction for synthetic biology: the Modular Overlap-Directed Assembly with Linkers (MODAL) strategy.

DOI：
10.1093/nar/gkt915
发表时间：
2014-01
期刊：
Nucleic acids research
影响因子：
14.9
作者：
Casini A;MacDonald JT;De Jonghe J;Christodoulou G;Freemont PS;Baldwin GS;Ellis T
通讯作者：
Ellis T

Removing the Bottleneck: Introducing cMatch - A Lightweight Tool for Construct-Matching in Synthetic Biology.