Centre for Synthetic Biology and Innovation at Imperial College

帝国理工学院合成生物学与创新中心

• 批准号: EP/G036004/1
• 负责人: Richard Kitney
• 金额: $ 600.17万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FG036004%2F1
• 关键词: Centre; Synthetic; Biology; Innovation; Imperial

Synthetic Biology aims to design and manufacture biologically-based devices and systems that do not already exist in the natural world, including the re-design and fabrication of existing biological systems. The case for investment in Synthetic Biology has been made in at least two major reports (i) the EU Report 2003, and (ii), more recently, Systems Biology: A Vision for Engineering and Medicine - by the Academy of Medical Sciences and The Royal Academy of Engineering. The strategic benefit of the area to the UK is described in the Government's Science and Innovation Investment Framework Document 2004 -2014. The aim is to establish a new and innovative research centre within the Institute of Systems and Synthetic Biology (IoSSB) called the Centre for Synthetic Biology and Innovation. This is directly in line with the Imperial College's strategic objectives of establishing a strong research base in Synthetic Biology. We believe that this will produce a step change in the UK's ability to generate sufficient IP in the area and be of significant benefit to the UK economy, in terms of licensing and spinout companies. This will principally be done through Imperial Innovations Group plc and the College's Business Development Unit. The Centre is to be housed in contiguous space. This will allow us to create a distinct identity which will act as a focus for Synthetic Biology research and training, both in the College and externally. The core of the application is the appointment of 3 new lecturers (2 in Engineering and 1 in Life Sciences). The new lecturers will be physically located in a single area, but with easy access to other members of staff working within the IoSSB and associated departments (all of the associated departments are on the South Kensington Campus). We will address societal and ethical issues surrounding Synthetic Biology. To this end, we have formed a partnership with the BIOS group at the LSE, led by Professor Nikolas Rose. In addition, we intend to work with Professor Robert Winston (who is Professor of Science and Society at Imperial College) to address issues of public engagement and trust and to engage with the central concerns of policy and regulation in this novel and rapidly developing area. We plan to organise regular meetings and workshops with both national and international collaborators. A principal aim of these meetings will be the definition of Grand Challenges in the field, including ethical and societal issues. Another aim is to actively nucleate Synthetic Biology research activities in the UK. We intend to establish clusters of research activity involving multiple institutions to tackle these Grand Challenges. We anticipate exchange visits for staff and students, as well as short placements. A Visiting Professor Scheme will be established in which a different internationally outstanding scholar will be funded for a period each year (typically 1-2 months) to visit the new centre to give seminars and a series of lectures that will be open to public and UK academic community. The meetings/workshops will be advertised widely in the UK academic community, including through the BBSRC networks in Synthetic Biology. We see the two annual meetings/workshops as a key element in creating research capacity in the UK where the Centre will actively promote and share expertise in Synthetic Biology with the wider UK community. Each workshop/meeting will also include a session devoted to societal, ethical and public engagement issues organised by our BIOS partners. In terms of sustainability, the aim is to have a steady flow of IP which is transferred via licensing, spinout companies and collaborative research (eg with industry). We anticipate that by 2014 there will be a rapidly developing industrial sector in Synthetic Biology in the UK/EU and internationally with which the Centre will be interacting. This is likely to include healthcare, renewable energy, materials, industrial processes and food technology.

合成生物学的目标是设计和制造自然界中尚不存在的基于生物的设备和系统，包括重新设计和制造现有的生物系统。至少在两份主要报告中提出了投资合成生物学的理由：(I)2003年欧盟报告，以及(Ii)最近由医学科学院和皇家工程院撰写的《系统生物学：工程和医学的愿景》。该地区对英国的战略利益在政府的科学和创新投资框架文件2004-2014中进行了描述。其目的是在系统和合成生物学研究所(IoSSB)内建立一个新的创新研究中心，称为合成生物学和创新中心。这与帝国理工学院建立强大的合成生物学研究基地的战略目标直接一致。我们相信，这将使英国在该领域产生足够知识产权的能力发生阶段性变化，并在许可和衍生公司方面对英国经济产生重大好处。这将主要通过帝国创新集团和学院的业务发展部门完成。该中心将设在毗连的空间内。这将使我们能够创造一个独特的身份，作为合成生物学研究和培训的重点，无论是在学院内还是在外部。申请的核心是任命3名新讲师(工程学2名，生命科学1名)。新讲师将设在一个单独的区域，但很容易接触到在IoSSB和相关部门工作的其他工作人员(所有相关部门都在南肯辛顿校区)。我们将解决围绕合成生物学的社会和伦理问题。为此，我们与伦敦政治经济学院的基本输入输出系统小组建立了合作伙伴关系，该小组由尼古拉斯·罗斯教授领导。此外，我们打算与罗伯特·温斯顿教授(帝国理工学院科学和社会教授)合作，解决公众参与和信任的问题，并参与这个新的和快速发展的领域的政策和监管的核心问题。我们计划定期组织与国家和国际合作者的会议和研讨会。这些会议的一个主要目的将是界定该领域的重大挑战，包括伦理和社会问题。另一个目标是积极推动合成生物学在英国的研究活动。我们打算建立涉及多个机构的研究活动集群，以应对这些重大挑战。我们期待着教职员工和学生的交流访问，以及短期实习。将建立一个访问教授计划，每年将资助一名不同的国际杰出学者访问新中心一段时间(通常为1-2个月)，向公众和英国学术界开放研讨会和一系列讲座。这些会议/研讨会将在英国学术界广泛宣传，包括通过BBSRC合成生物学网络。我们认为这两个年度会议/研讨会是在英国建立研究能力的关键因素，中心将在那里积极促进合成生物学并与更广泛的英国社区分享专业知识。每个研讨会/会议还将包括由我们的基本输入输出系统合作伙伴组织的专门讨论社会、道德和公共参与问题的会议。在可持续性方面，目标是有稳定的知识产权流动，通过许可、衍生公司和合作研究(如与行业合作)进行转移。我们预计，到2014年，合成生物学将在英国/欧盟和国际上形成一个快速发展的工业部门，该中心将与之互动。这可能包括医疗保健、可再生能源、材料、工业流程和食品技术。

项目成果

Design of a prototype flow microreactor for synthetic biology in vitro

• DOI: 10.1039/c3lc50231g
• 发表时间: 2013-01-01
• 期刊: LAB ON A CHIP
• 影响因子: 6.1
• 作者: Boehm, Christian R.;Freemont, Paul S.;Ces, Oscar
• 通讯作者: Ces, Oscar

Five rules of thumb for post-ELSI interdisciplinary collaborations

• DOI: 10.1080/23299460.2016.1177867
• 发表时间: 2016-01-01
• 期刊: JOURNAL OF RESPONSIBLE INNOVATION
• 影响因子: 3.9
• 作者: Balmer, Andrew S.;Calvert, Jane;Martin, Paul
• 通讯作者: Martin, Paul

The Sixth International Meeting on Synthetic Biology (SB6.0) special issue editorial.

第六届国际合成生物学会议（SB6.0）特刊社论。

• DOI: 10.1021/sb500085b
• 发表时间: 2014
• 期刊: ACS synthetic biology
• 影响因子: 4.7
• 作者: Cai Y

One-pot DNA construction for synthetic biology: the Modular Overlap-Directed Assembly with Linkers (MODAL) strategy.

• DOI: 10.1093/nar/gkt915
• 发表时间: 2014-01
• 期刊: Nucleic acids research
• 影响因子: 14.9
• 作者: Casini A;MacDonald JT;De Jonghe J;Christodoulou G;Freemont PS;Baldwin GS;Ellis T
• 通讯作者: Ellis T

Engineering and ethical perspectives in synthetic biology. Rigorous, robust and predictable designs, public engagement and a modern ethical framework are vital to the continued success of synthetic biology.

• DOI: 10.1038/embor.2012.81
• 发表时间: 2012-06-29
• 期刊: EMBO REPORTS
• 影响因子: 7.7
• 作者: Anderson, James;Strelkowa, Natalja;Stan, Guy-Bart;Douglas, Thomas;Savulescu, Julian;Barahona, Mauricio;Papachristodoulou, Antonis
• 通讯作者: Papachristodoulou, Antonis