PROSTAGLANDINS AND VASOPRESSIN ACTION

前列腺素和加压素的作用

• 批准号: 3445949
• 负责人: BRIAN A JACKSON
• 金额: $ 5.15万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-04-01 至 1986-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3445949
• 关键词: cyclic AMP; excretion; hormone biosynthesis; hormone regulation /control mechanism; kidney function; kidney metabolism; kidney pharmacology; prostaglandins; renal medulla; renal tubular transport; vasopressins

The present research proposal aims to define the biochemical mechanisms involved in the interaction between antidiuretic hormone (vasopressin) and prostaglandins in the kidney. To circumvent the problem of tissue heterogeneity encountered in most previous studies, this interaction will be examined specifically in the collecting tubule microdissected from the inner medulla of the rat kidney. The specific aims of this proposal will be: 1) a) To determine the effects of inhibition of endogenous prostaglandin synthesis on vasopressin (AVP)-dependent cAMP formation in the collecting tubule, b) to determine the effects of hyperosmolality and specific solutes on prostaglandin synthesis in the collecting tubule and their implications for AVP-dependent cAMP formation, c) to assess the potential role of calcium in the interaction between prostaglandins and vasopressin. 2) To determine whether AVP stimulates prostaglandin synthesis in the collecting tubule, and if so, to determine the mechanism of stimulation. 3) To determine whether altered prostaglandin synthesis in the collecting tubule may be associated wih specific syndromes of impaired water excretion.

目前的研究计划旨在确定生物化学机制 参与抗利尿激素（加压素）和 肾中的肾上腺素。 为了避开组织的问题 在大多数以前的研究中遇到的异质性，这种相互作用将 特别是在收集小管显微解剖检查，从 大鼠肾脏的内髓质。 该提案的具体目标将 a）确定内源性抑制的影响， 前列腺素合成对血管加压素（AVP）依赖性cAMP形成的影响 收集小管，B）以确定高渗透压的影响， 对集合小管中前列腺素合成的特异性溶质， 它们对AVP依赖性cAMP形成的影响，c）评估 钙在甘草素与 加压素 2)为了确定AVP是否刺激前列腺素 在集合小管合成，如果是这样，以确定机制 的刺激。 3)为了确定前列腺素合成的改变是否会影响 集合小管可能与受损的特定综合征有关， 水排泄

项目成果

Modulation of vasopressin-sensitive cyclic AMP levels by calcium in papillary collecting tubules.

乳头集合管中钙对加压素敏感的环 AMP 水平的调节。

• DOI: 10.1016/0303-7207(88)90075-5
• 发表时间: 1988
• 期刊: Molecular and cellular endocrinology
• 影响因子: 4.1
• 作者: Jackson,BA

Renal prostaglandin E2 synthesis in the Brattleboro homozygous diabetes insipidus rat.

• DOI: 10.1016/0262-1746(86)90026-0
• 发表时间: 1986-04
• 期刊: Prostaglandins, leukotrienes, and medicine
• 作者: B. Jackson

Salt-sensitive hypertension: contribution of chloride.

• DOI: 10.1126/science.6322303
• 发表时间: 1984-03
• 期刊: Science
• 影响因子: 56.9
• 作者: S. Whitescarver;C. Ott;B. Jackson;G. Guthrie;T. Kotchen

Dissociation of hyperreninemia and renal prostaglandin synthesis in the adrenalectomized rat.

肾上腺切除大鼠中高肾素血症和肾前列腺素合成的分离。

• DOI: 10.1016/0090-6980(86)90232-7
• 发表时间: 1986
• 期刊: Prostaglandins
• 作者: Boucher,LD;Kotchen,TA;Jackson,BA
• 通讯作者: Jackson,BA

Prostaglandin E2 synthesis in the inner medullary collecting duct of the rat: implications for vasopressin-dependent cyclic AMP formation.

大鼠内髓集合管中前列腺素 E2 的合成：对加压素依赖性环 AMP 形成的影响。

• DOI: 10.1002/jcp.1041290109
• 发表时间: 1986
• 期刊: Journal of cellular physiology
• 影响因子: 5.6
• 作者: Jackson,BA