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A 500MHz 13C-cryoprobe and NMR Spectrometer @ Bristol

布里斯托尔的 500MHz 13C 冷冻探针和核磁共振波谱仪

基本信息

批准号：
EP/L011999/1
负责人：
Craig Butts
金额：
$ 0.77万
依托单位：
University of Bristol
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2014
资助国家：
英国
起止时间：
2014 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FL011999%2F1
关键词：
500MHz 13C cryoprobe NMR Spectrometer

项目摘要

Nuclear Magnetic Resonance (NMR) Spectroscopy is the most information-rich tool for molecular structure analysis, allowing scientists to probe the environment of individual atoms in molecules. The NMR analysis of carbon atoms (specifically their nuclei) is, in turn, the most desirable technique as carbon is ubiquitous in the vast majority of cutting-edge chemical compounds being studied in UK research centres - from plastics and polymers, through detergents, petrochemicals to modern pharmaceuticals and organic electronics. Unfortunately, NMR of carbon suffers from a serious challenge - it is incredibly insensitive, primarily due to the very low-abundance of the NMR-active carbon-13 (13C) nucleus.This project will install a cutting-edge 13C-sensitive NMR cryogenic probe into the existing large-scale University of Bristol NMR Facility, which serves hundreds of researchers studying a wide range of scientific problems, from manipulation of biosynthetic processes in organisms, ultra-efficient chemical catalysis to the development of controlled nano-architectures with applications in nanoscience. The superconducting coils in this cryogenic NMR probe increase the sensitivity for detection of weak 13C NMR signals by around 10-fold over the most modern room temperature probes used in the vast majority of NMR facilities (including Bristol's). The sensitivity of this 13C-cryoprobe will fill a substantial void in current capabilities of the Bristol NMR Facility, enabling a suite of otherwise impractical NMR techniques to be applied to this broad spectrum of scientific problems - in particular making experiments up to 100-times faster (so minutes or hours for data collection, rather than days or even weeks). The incorporation of a 13C-cryoprobe into the University of Bristol NMR Facility will create a UK-leading NMR centre that will compete with the best laboratories for these studies anywhere in the world. This instrument will be integrated into the current UoB NMR Facility, alongside the existing suite of 9 other liquids NMR instruments (11 by late summer) and will be supported by an expert team of support staff who between them have over 5 decades of experience in supporting major multi-project, multi-user NMR instrumentation. It is this combination of cutting-edge technology, a highly efficient UoB NMR Facility and the associated research environment that will ensure a highly effective use of this equipment investment, and ensure optimal results for the scientists relying on the capabilities of this critical hardware.

核磁共振（NMR）光谱学是分子结构分析中信息最丰富的工具，使科学家能够探测分子中单个原子的环境。碳原子（特别是原子核）的核磁共振分析是最理想的技术，因为碳在英国研究中心研究的绝大多数尖端化合物中无处不在——从塑料和聚合物，到洗涤剂，石油化工产品，再到现代制药和有机电子产品。不幸的是，碳核磁共振面临着一个严峻的挑战——它非常不敏感，这主要是由于核磁共振活性碳-13 （13C）核的丰度非常低。该项目将在布里斯托尔大学现有的大型核磁共振设施中安装一个尖端的13c敏感核磁共振低温探针，该设施为数百名研究人员提供广泛的科学问题，从生物合成过程的操纵，超高效化学催化到纳米科学应用中受控纳米结构的开发。这种低温核磁共振探头中的超导线圈比绝大多数核磁共振设施（包括布里斯托尔的）中使用的最现代的室温探头提高了探测弱13C核磁共振信号的灵敏度约10倍。这种13c低温探针的灵敏度将填补布里斯托尔核磁共振设备目前能力的实质性空白，使一套不切实际的核磁共振技术能够应用于广泛的科学问题-特别是使实验速度提高100倍（因此数据收集只需几分钟或几小时，而不是几天甚至几周）。布里斯托尔大学核磁共振设备的13c冷冻探针的合并将创建一个英国领先的核磁共振中心，将与世界上最好的实验室竞争这些研究。该仪器将与现有的9台其他液体核磁共振仪器（到夏末将有11台）一起集成到目前的大华银行核磁共振设施中，并将由一个专家支持团队提供支持，他们在支持主要的多项目，多用户核磁共振仪器方面拥有超过50年的经验。正是这种尖端技术、高效UoB核磁共振设施和相关研究环境的结合，将确保这项设备投资的高效利用，并确保依靠这一关键硬件功能的科学家获得最佳结果。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Heterologous expression reveals the biosynthesis of the antibiotic pleuromutilin and generates bioactive semi-synthetic derivatives.

DOI：
10.1038/s41467-017-01659-1
发表时间：
2017-11-28
期刊：
Nature communications
影响因子：
16.6
作者：
Alberti F;Khairudin K;Venegas ER;Davies JA;Hayes PM;Willis CL;Bailey AM;Foster GD
通讯作者：
Foster GD

Perhydrohelicenes and other diamond-lattice based hydrocarbons: the choreography of inversion.