High-field NMR Spectroscopy for Biomolecular Research

用于生物分子研究的高场核磁共振波谱

• 批准号: BB/F011539/1
• 负责人: Craig Butts
• 金额: $ 31.08万
• 依托单位: University of Bristol
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=BB%2FF011539%2F1
• 关键词: field; NMR; Spectroscopy; Biomolecular; Research

NMR spectroscopy is the most information-rich analytical technique available to molecular research, but requires a high level of instrumentation to maximise the benefits of such analyses. In particular, its' application to materials of biological interest requires high quality instrumentation, with powerful superconducting magnets for signal resolution (500MHz or greater) and maximum sensitivity for proton nuclei. The Bristol NMR Facility currently supports a substantial number of researchers in the Biomolecular field and current NMR hardware is no longer sufficient to fulfil the demands of the cutting edge research projects conducted - which covers areas such as biosynthesis, protein structure and dynamics, potential disease treatments (Alzheimers and Cystic Fybrosis), bionanotechnology and membrane protein-ligand interactions. To this end, a modern 500MHz automated NMR spectrometer is required enabling these research fields to take advantage of the latest hardware and experimental developments required to achieve their aims.

核磁共振波谱是分子研究中可用的信息最丰富的分析技术，但需要高水平的仪器来最大限度地发挥这种分析的好处。特别是，它在生物材料中的应用需要高质量的仪器，具有强大的超导磁体的信号分辨率（500MHz或更高）和质子核的最大灵敏度。布里斯托尔核磁共振设施目前支持大量生物分子领域的研究人员，目前的核磁共振硬件不再足以满足前沿研究项目的需求，这些项目涵盖了生物合成、蛋白质结构和动力学、潜在疾病治疗（阿尔茨海默氏症和囊性纤维化）、生物纳米技术和膜蛋白-配体相互作用等领域。为此，需要一台现代化的500MHz自动核磁共振光谱仪，使这些研究领域能够利用最新的硬件和实验发展来实现其目标。

项目成果

Perhydrohelicenes and other diamond-lattice based hydrocarbons: the choreography of inversion.

• DOI: 10.1039/c7sc01759f
• 发表时间: 2017-09-01
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Alder RW;Butts CP;Sessions RB
• 通讯作者: Sessions RB

Synthesis of Diarylheptanoid Scaffolds Inspired by Calyxins I and J

• DOI: 10.1021/acs.orglett.5b01848
• 发表时间: 2015-08-07
• 期刊: ORGANIC LETTERS
• 影响因子: 5.2
• 作者: Ackrill, Thomas D.;Sparkes, Hazel A.;Willis, Christine L.
• 通讯作者: Willis, Christine L.

Platform Synthetic Lectins for Divalent Carbohydrate Recognition in Water.

平台合成凝集素用于水中的二价碳水化合物识别。

• DOI: 10.1002/anie.201603082
• 发表时间: 2016-08-01
• 期刊: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
• 影响因子: 16.6
• 作者: Carter, Tom S.;Mooibroek, Tiddo J.;Stewart, Patrick F. N.;Crump, Matthew P.;Galan, M. Carmen;Davis, Anthony P.
• 通讯作者: Davis, Anthony P.

Enantiodivergent Synthesis of Allenes by Point-to-Axial Chirality Transfer.

• DOI: 10.1002/anie.201804446
• 发表时间: 2018-07-02
• 期刊: Angewandte Chemie (International ed. in English)
• 作者: Armstrong RJ;Nandakumar M;Dias RMP;Noble A;Myers EL;Aggarwal VK
• 通讯作者: Aggarwal VK

Assembly-line synthesis of organic molecules with tailored shapes.

• DOI: 10.1038/nature13711
• 发表时间: 2014-09-11
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Burns, Matthew;Essafi, Stephanie;Bame, Jessica R.;Bull, Stephanie P.;Webster, Matthew P.;Balieu, Sebastien;Dale, James W.;Butts, Craig P.;Harvey, Jeremy N.;Aggarwal, Varinder K.
• 通讯作者: Aggarwal, Varinder K.