High-field NMR Spectroscopy for Biomolecular Research

核磁共振光谱学是可用于分子研究的信息最丰富的分析技术，但需要高水平的仪器才能最大限度地发挥此类分析的好处。特别是，它在具有生物意义的材料上的应用需要高质量的仪器，具有强大的超导磁体，以实现信号分辨率(500 MHz或更高)和质子核的最高灵敏度。布里斯托尔核磁共振设施目前支持生物分子领域的大量研究人员，目前的核磁共振硬件不再足以满足所进行的尖端研究项目的需求，这些项目涵盖生物合成、蛋白质结构和动力学、潜在的疾病治疗(阿尔茨海默氏症和囊性萎缩症)、生物纳米技术和膜蛋白质-配体相互作用等领域。为此，需要一台现代化的500 MHz自动核磁共振光谱仪，使这些研究领域能够利用实现其目标所需的最新硬件和实验发展。

NMR spectroscopy is the most information-rich analytical technique available to molecular research, but requires a high level of instrumentation to maximise the benefits of such analyses. In particular, its' application to materials of biological interest requires high quality instrumentation, with powerful superconducting magnets for signal resolution (500MHz or greater) and maximum sensitivity for proton nuclei. The Bristol NMR Facility currently supports a substantial number of researchers in the Biomolecular field and current NMR hardware is no longer sufficient to fulfil the demands of the cutting edge research projects conducted - which covers areas such as biosynthesis, protein structure and dynamics, potential disease treatments (Alzheimers and Cystic Fybrosis), bionanotechnology and membrane protein-ligand interactions. To this end, a modern 500MHz automated NMR spectrometer is required enabling these research fields to take advantage of the latest hardware and experimental developments required to achieve their aims.