Chimeric insect-specific flaviviruses: a new generation of diagnostics and vaccines against mosquito-borne viral disease

嵌合昆虫特异性黄病毒：针对蚊媒病毒性疾病的新一代诊断方法和疫苗

• 批准号: nhmrc : 1138611
• 负责人: Dr Helle Bielefeldt-Ohmann
• 金额: $ 37.18万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/chimeric-insect-specific-viral-disease/1318807
• 关键词: Chimeric; insect; specific; flaviviruses; new

Dengue, Zika and West Nile are mosquito-borne viruses that cause disease outbreaks world-wide. We will develop safe, cheap and authentic diagnostics and vaccines against these diseases based on novel viruses that only infect mosquitoes. This is a timely paradigm shift for vaccine and diagnostic development. This innovative strategy will have high impact in the field of vector-borne viral diseases and provide a blueprint to develop safe diagnostics and vaccines for other mosquito-borne diseases.

登革热、寨卡病毒和西尼罗河病毒是蚊子传播的病毒，会导致全球范围内的疾病爆发。我们将基于只感染蚊子的新型病毒，开发针对这些疾病的安全、廉价和可靠的诊断方法和疫苗。这是疫苗和诊断发展的及时转变。这一创新战略将对病媒传播的病毒性疾病领域产生重大影响，并为开发其他蚊媒疾病的安全诊断方法和疫苗提供蓝图。