RF COIL DESIGN FOR BIOLOGICAL NUCLEAR MAGNETIC RESONANCE

生物核磁共振射频线圈设计

• 批准号: 3446713
• 负责人: Richard W. Briggs
• 金额: $ 5.51万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-04-01 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3446713
• 关键词: brain disorder diagnosis; brain imaging /visualization /scanning; clinical biomedical equipment; heart disorder diagnosis; image processing; kidney disorder diagnosis; magnetic field; nuclear magnetic resonance spectroscopy

LONG-TERM OBJECTIVES 1. To calculate magnetic field profiles of NMR coils of different geometries, and the signal detected by them from different regions in space with various pulse sequences. 2. To use this information to design tailor-made NMR coils with good homogeneity and spatial selectivity properties for specific in vivo organs and tissue. This will hopefully allow better discrimination of signal from desired tissue vs. undesired tissue, better signal-to-noise ratio, and more reliable measurements of relaxation times and kinetics. SPECIFIC AIMS 1. To calculate and graphically display radiofrequency magnetic field profiles and contours generated by NMR coils of various geometries. To calculate and display signal intensities obtained from different regions of a sample with these coils using different commonly employed pulse sequences as a function of RF power and pulse duration and inter-pulse delay time. 2. To use such information to design transmitter and receiver coils with desired properties of field homogeneity, spatial selectivity, and sensitivity for applications in in vivo biological nuclear magnetic resonance (NMR). 3. To verify these calculations with experimental data from phantom samples and coils constructed to geometrical specifications suggested by theory. 4. To build coils of successful geometries to be compatible with in vivo physiology and anatomy, and apply them to study metabolism. METHODOLOGY 1. Write software to perform the calculations and graphics displays on a VAX 11/780, using the Biot Law. 2. Construct coils from materials selected for biocompatibility and electromagnetic performance. Measure induced fields on bench with synthesizer, oscilloscope, and search coil. Measure S/N on spectrometer with phantoms at different spatial locations. 3. Apply coils to study of in vivo metabolism of selected organs, viz., brain, heart, and kidney.

长期目标 1.计算不同核磁共振线圈的磁场分布 几何图形，以及它们从空间不同区域探测到的信号 具有各种脉冲序列。 2.利用这些信息设计具有良好性能的定制核磁共振线圈 体内特定器官的均质性和空间选择性 和纸巾。这将有望更好地区分信号和 想要的组织与不想要的组织、更好的信噪比以及更多 松弛时间和动力学的可靠测量。 具体目标 1.计算并图形化显示射频磁场 由各种几何形状的核磁共振线圈生成的轮廓和等高线。至 计算和显示从不同区域获得的信号强度 使用不同常用脉冲序列的具有这些线圈的样本 作为RF功率、脉冲持续时间和脉冲间延迟时间的函数。 2.使用这些信息来设计发射器和接收器线圈 所需的场同质性、空间选择性和 活体生物核磁应用的灵敏度 共振(核磁共振)。 3.用体模样本的实验数据验证这些计算 以及按理论建议的几何规格构造的线圈。 4.构建与体内兼容的成功几何形状的线圈 生理学和解剖学，并将其应用于新陈代谢研究。 方法论 1.编写软件，在计算机上执行计算和图形显示 VAX 11/780，使用毕奥定律。 2.用生物相容性好的材料构建线圈 电磁性能。在工作台上测量感应场 合成器、示波器和搜索线圈。在光谱仪上测量S/N 在不同的空间位置有幻影。 3.应用线圈研究选定器官的体内代谢，即 大脑、心脏和肾脏。