Core--Neuroimaging

核心--神经影像

• 批准号: 6331842
• 负责人: Richard W. Briggs
• 金额: $ 18.5万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-06-01 至 2001-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6331842
• 关键词: bioimaging /biomedical imaging; biomedical facility; brain imaging /visualization /scanning; clinical research; functional magnetic resonance imaging; human subject

The purpose of Neuroimaging Core B is to provide the subprojects of this program project grant with the facilities, technical expertise, and methodology, to successfully apply fMRI to the study and treatment of aphasia and related disorders caused by stroke and other neurological disorders. This will include all aspects of data acquisition (including interface of task presentation and performance monitoring with the MR scanning), data transfer, data archiving, and data analysis (including statistics). In particular, it will be the function of the core to provide optimized MRI sequences for anatomic, angiographic and functional images of the brain for subjects selected for fMRI. In this program project proposal, fMRI will be used by the various subprojects to answer two types of questions. Every fMRI component of the subprojects in this proposal will address one or both of the following questions for the relevant language and cognitive functions. (1) How do damaged brain systems operate differently from normal brain systems in performing various tasks? To answer this question, functional brain maps of brain- damaged patients will be compared to those of neurologically normal controls on relevant cognitive tasks. (2) How does rehabilitation change brain systems responsible for relevant cognitive activities in brain- damaged individuals? To anser this question, functional brain maps will be acquired for relevant cognitive activities before and after the individual patient receives rehabilitation.

神经影像学核心B的目的是为该项目的子项目提供设施、技术专长和方法，以成功地将功能磁共振成像应用于中风和其他神经系统疾病引起的失语症和相关疾病的研究和治疗。这将包括数据采集的所有方面（包括任务呈现和性能监测与MR扫描的接口）、数据传输、数据存档和数据分析（包括统计）。特别是，它将是核心的功能，以提供优化的MRI序列的解剖，血管造影和功能图像的大脑为受试者选择的功能磁共振成像。在这个计划项目建议书中，功能磁共振成像将被用于各个子项目来回答两种类型的问题。本提案中的子项目的每个功能磁共振成像组件将解决以下相关语言和认知功能的一个或两个问题。(1)受损的大脑系统在执行各种任务时与正常大脑系统的运作方式有何不同？为了回答这个问题，将脑损伤患者的功能脑图与神经学正常对照组在相关认知任务上的功能脑图进行比较。(2)康复治疗如何改变脑损伤患者负责相关认知活动的脑系统？为了回答这个问题，将获得功能脑地图的相关认知活动之前和之后的个别患者接受康复。