RF COIL DESIGN FOR BIOLOGICAL NUCLEAR MAGNETIC RESONANCE

生物核磁共振射频线圈设计

• 批准号: 3446712
• 负责人: Richard W. Briggs
• 金额: $ 5.27万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-04-01 至 1988-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3446712
• 关键词: brain imaging /visualization /scanning; clinical biomedical equipment; heart disorder diagnosis; image processing; kidney disorder diagnosis; magnetic field; nervous system disorder diagnosis; nuclear magnetic resonance spectroscopy

LONG-TERM OBJECTIVES 1. To calculate magnetic field profiles of NMR coils of different geometries, and the signal detected by them from different regions in space with various pulse sequences. 2. To use this information to design tailor-made NMR coils with good homogeneity and spatial selectivity properties for specific in vivo organs and tissue. This will hopefully allow better discrimination of signal from desired tissue vs. undesired tissue, better signal-to-noise ratio, and more reliable measurements of relaxation times and kinetics. SPECIFIC AIMS 1. To calculate and graphically display radiofrequency magnetic field profiles and contours generated by NMR coils of various geometries. To calculate and display signal intensities obtained from different regions of a sample with these coils using different commonly employed pulse sequences as a function of RF power and pulse duration and inter-pulse delay time. 2. To use such information to design transmitter and receiver coils with desired properties of field homogeneity, spatial selectivity, and sensitivity for applications in in vivo biological nuclear magnetic resonance (NMR). 3. To verify these calculations with experimental data from phantom samples and coils constructed to geometrical specifications suggested by theory. 4. To build coils of successful geometries to be compatible with in vivo physiology and anatomy, and apply them to study metabolism. METHODOLOGY 1. Write software to perform the calculations and graphics displays on a VAX 11/780, using the Biot Law. 2. Construct coils from materials selected for biocompatibility and electromagnetic performance. Measure induced fields on bench with synthesizer, oscilloscope, and search coil. Measure S/N on spectrometer with phantoms at different spatial locations. 3. Apply coils to study of in vivo metabolism of selected organs, viz., brain, heart, and kidney.

长期目标 1.为了计算不同厚度的核磁共振线圈的磁场分布， 几何形状，以及它们从空间不同区域检测到的信号 各种脉冲序列。 2.利用这些信息来设计定制的核磁共振线圈， 特定体内器官的均匀性和空间选择性特性 和组织。 这将有望允许更好地区分来自 所需组织与非所需组织、更好的信噪比等 弛豫时间和动力学的可靠测量。 具体目标 1.计算并图形化显示射频磁场 由各种几何形状的NMR线圈产生的轮廓和轮廓。 到 计算并显示从不同区域获得的信号强度 具有这些线圈的样品使用不同的常用脉冲序列 作为RF功率和脉冲持续时间以及脉冲间延迟时间的函数。 2.使用这些信息来设计发射器和接收器线圈， 场均匀性、空间选择性和 在体内生物核磁共振中应用的灵敏度 共振（NMR）。 3.为了用体模样本的实验数据验证这些计算， 并且线圈构造成理论建议的几何规格。 4.为了构建成功几何形状的弹簧圈，以与体内兼容， 生理学和解剖学，并将其应用于研究新陈代谢。 方法 1.编写软件来执行计算和图形显示在一个 VAX 11/780，使用毕奥定律。 2.使用生物相容性材料构建弹簧圈， 电磁性能 在工作台上测量感应场， 合成器示波器和探测线圈 在光谱仪上测量S/N 在不同的空间位置有幻影。 3.应用线圈研究选定器官的体内代谢，即， 大脑心脏和肾脏