STUDIES OF SPERM CAPACITATION AND HYPERACTIVATION

精子获能和过度激活的研究

基本信息

项目摘要

The goals of this research are to elucidate the relationship of hyperactivated sperm motility to sperm capacitation and fertilization and to examine molecular events associated with the onset of hyperactivation. Only small percentages of human spermatozoa have been observed undergoing hyperactivation in vitro, yet it is assumed on the basis of studies of several mammalian species, that hyperactivation precedes fertilization in vivo. The hamster will be used as a model system because hamster spermatozoa may be induced to hyperactivate in a defined medium in vitro and may also be observed moving towards the site of fertilization in the oviduct. The methods to be used are comparative videoanalysis of the onset of hyperactivated motility in vitro and in vivo, using labeled lectins and monoclonal antibodies to monitor cell surface changes during hyperactivation and to identify membrane components associated with hyperactivation, and comparing the success of non-hyperactivated spermatozoa with that of hyperactivated spermatozoa in achieving the site of fertilization in the oviduct and penetrating the cumulus matrix. Information learned from the hamster system could eventually be applied to the understanding of human fertilization, e.g. whether normal spermatozoa must be able to hyperactivate under the correct environmental conditions and how hyperactivation might be prevented as a contraceptive technique.
本研究的目的是阐明的关系

项目成果

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Susan Stevens Suarez其他文献

Susan Stevens Suarez的其他文献

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{{ truncateString('Susan Stevens Suarez', 18)}}的其他基金

"Physical and Chemical Cues that Guide Sperm Migration"
“引导精子迁移的物理和化学线索”
  • 批准号:
    8184835
  • 财政年份:
    2012
  • 资助金额:
    $ 5万
  • 项目类别:
"Physical and Chemical Cues that Guide Sperm Migration"
“引导精子迁移的物理和化学线索”
  • 批准号:
    8437156
  • 财政年份:
    2012
  • 资助金额:
    $ 5万
  • 项目类别:
"Physical and Chemical Cues that Guide Sperm Migration"
“引导精子迁移的物理和化学线索”
  • 批准号:
    8644826
  • 财政年份:
    2012
  • 资助金额:
    $ 5万
  • 项目类别:
Sperm Motility Modulations Crucial to Fertilization
精子活力调节对受精至关重要
  • 批准号:
    8013892
  • 财政年份:
    2010
  • 资助金额:
    $ 5万
  • 项目类别:
Sperm Motility Modulations Crucial to Fertilization
精子活力调节对受精至关重要
  • 批准号:
    7760210
  • 财政年份:
    2010
  • 资助金额:
    $ 5万
  • 项目类别:
IDENTIFICATION OF BINDING SITE SPERM IN THE OVIDUCT
输卵管中精子结合位点的识别
  • 批准号:
    6140033
  • 财政年份:
    2001
  • 资助金额:
    $ 5万
  • 项目类别:
Reproductive Sciences Symposium
生殖科学研讨会
  • 批准号:
    8295966
  • 财政年份:
    1998
  • 资助金额:
    $ 5万
  • 项目类别:
SPERM CAPACITATION AND HYPERACTIVATION
精子获能和过度激活
  • 批准号:
    3316955
  • 财政年份:
    1985
  • 资助金额:
    $ 5万
  • 项目类别:
SPERM CAPACITATION AND HYPERACTIVATION
精子获能和过度激活
  • 批准号:
    3316958
  • 财政年份:
    1985
  • 资助金额:
    $ 5万
  • 项目类别:
SPERM CAPACITATION AND HYPERACTIVATION
精子获能和过度激活
  • 批准号:
    2197844
  • 财政年份:
    1985
  • 资助金额:
    $ 5万
  • 项目类别:

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分析输卵管癌前细胞的液体辅助传播
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用于输卵管微创成像的先进输卵管镜
  • 批准号:
    9754821
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    2016
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输卵管的多模态光学成像
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    358499
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用于输卵管微创成像的先进输卵管镜
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    9352340
  • 财政年份:
    2016
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用于输卵管微创成像的先进输卵管镜
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Experimental analysis of the molecular carcinogenesis of ovarian high grade serous carcinoma originated from fallopian tubes
输卵管卵巢高级别浆液性癌分子癌变的实验分析
  • 批准号:
    15H04985
  • 财政年份:
    2015
  • 资助金额:
    $ 5万
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    Grant-in-Aid for Scientific Research (B)
SALPINGOSONOGRAPH FOR EVALUATION OF FALLOPIAN TUBES
用于评估输卵管的输卵管超声检查
  • 批准号:
    2207125
  • 财政年份:
    1996
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    $ 5万
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DIRECT GONADOTROPIN REGULATION OF HUMAN FALLOPIAN TUBES
促性腺激素对人类输卵管的直接调节
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    1994
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    $ 5万
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DIRECT GONADOTROPIN REGULATION OF HUMAN FALLOPIAN TUBES
促性腺激素对人类输卵管的直接调节
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    2403403
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    1994
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    $ 5万
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