STUDIES OF SPERM CAPACITATION AND HYPERACTIVATION
精子获能和过度激活的研究
基本信息
- 批准号:3448070
- 负责人:
- 金额:$ 5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1985
- 资助国家:美国
- 起止时间:1985-04-01 至 1988-03-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The goals of this research are to elucidate the relationship of
hyperactivated sperm motility to sperm capacitation and fertilization and
to examine molecular events associated with the onset of hyperactivation.
Only small percentages of human spermatozoa have been observed undergoing
hyperactivation in vitro, yet it is assumed on the basis of studies of
several mammalian species, that hyperactivation precedes fertilization in
vivo. The hamster will be used as a model system because hamster
spermatozoa may be induced to hyperactivate in a defined medium in vitro
and may also be observed moving towards the site of fertilization in the
oviduct. The methods to be used are comparative videoanalysis of the onset
of hyperactivated motility in vitro and in vivo, using labeled lectins and
monoclonal antibodies to monitor cell surface changes during
hyperactivation and to identify membrane components associated with
hyperactivation, and comparing the success of non-hyperactivated
spermatozoa with that of hyperactivated spermatozoa in achieving the site
of fertilization in the oviduct and penetrating the cumulus matrix.
Information learned from the hamster system could eventually be applied to
the understanding of human fertilization, e.g. whether normal spermatozoa
must be able to hyperactivate under the correct environmental conditions
and how hyperactivation might be prevented as a contraceptive technique.
本研究的目的是阐明的关系
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Susan Stevens Suarez其他文献
Susan Stevens Suarez的其他文献
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{{ truncateString('Susan Stevens Suarez', 18)}}的其他基金
"Physical and Chemical Cues that Guide Sperm Migration"
“引导精子迁移的物理和化学线索”
- 批准号:
8184835 - 财政年份:2012
- 资助金额:
$ 5万 - 项目类别:
"Physical and Chemical Cues that Guide Sperm Migration"
“引导精子迁移的物理和化学线索”
- 批准号:
8437156 - 财政年份:2012
- 资助金额:
$ 5万 - 项目类别:
"Physical and Chemical Cues that Guide Sperm Migration"
“引导精子迁移的物理和化学线索”
- 批准号:
8644826 - 财政年份:2012
- 资助金额:
$ 5万 - 项目类别:
Sperm Motility Modulations Crucial to Fertilization
精子活力调节对受精至关重要
- 批准号:
8013892 - 财政年份:2010
- 资助金额:
$ 5万 - 项目类别:
Sperm Motility Modulations Crucial to Fertilization
精子活力调节对受精至关重要
- 批准号:
7760210 - 财政年份:2010
- 资助金额:
$ 5万 - 项目类别:
IDENTIFICATION OF BINDING SITE SPERM IN THE OVIDUCT
输卵管中精子结合位点的识别
- 批准号:
6140033 - 财政年份:2001
- 资助金额:
$ 5万 - 项目类别:
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