Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes

用于输卵管微创成像的先进输卵管镜

基本信息

  • 批准号:
    9352340
  • 负责人:
  • 金额:
    $ 33.44万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-09-15 至 2020-06-30
  • 项目状态:
    已结题

项目摘要

The fallopian tubes harbor serous tubal intraepithelial carcinoma (STIC), the putative precursor to high- grade serous ovarian carcinoma, the deadliest form of this disease with a 70% mortality rate. Early detection of STIC could save lives as well as prevent thousands of unnecessary prophylactic salpingo-oophorectomies. Unfortunately, early disease of the fallopian tubes is undetectable via conventional whole-body imaging technologies, and noninvasive methods of screening for ovarian cancer are not effective. The fallopian tubes can be visualized during laparoscopy using high resolution techniques such as optical coherence tomography (OCT) and multiphoton microscopy (MPM). The investigators have clearly shown the ability of these techniques to differentiate normal from diseased tissues and have demonstrated laparoscopic imaging systems in women. However, the general anesthesia needed for laparoscopy makes its use as a diagnostic or surveillance technique unattractive, even in high risk women. We propose to enable high-sensitivity, high-resolution imaging of the fallopian tube in an office setting. Our salpingoscope will be inserted under local anesthesia through the vagina into the rectouterine pouch, providing minimally-invasive access to the distal fallopian tube and also enabling imaging of the ovaries and exterior uterine wall. White light, large field-of-view imaging for navigation will be combined with sensitive OCT and MPM imaging for early detection of neoplasia. Steering and biopsy capability will further enhance the utility and usability of this system. The proposed specific aims are: Specific Aim 1: Develop a multipurpose near-infrared laser. A novel, compact, robust, femtosecond fiber-based laser operating at a center wavelength of 1300 nm will be developed, which will function as an ideal source for both the OCT and MPM subsystems, and be highly functional in a fiber-based endoscopic system in a medical office environment. Specific Aim 2: Develop an advanced transvaginal salpingoscope. A 3 mm diameter, steerable, high capability salpingoscope will be developed which will include a white light imaging channel for navigation, an OCT/MPM channel for high resolution investigation of tissue microstructure and function in suspicious regions, a biopsy channel for tissue sampling and an irrigation port to enable organ floatation or apply dye. Specific Aim 3. Evaluate the operational and diagnostic capability of the salpingoscope. The mechanical and operational performance of the salpingoscope will be assessed with ex vivo human tissues, in vivo in a sheep model, and finally in vivo in women in a limited pilot study. In the near term, we will provide the of hundreds of thousands of women at high risk for ovarian cancer an opportunity to detect early disease and delay or avoid the life-altering (and possibly shortening) prophylactic salpingo-oophorectomy. The salpingoscope may also find broad utility for imaging of other pelvic disorders.
输卵管内有浆液性输卵管上皮内癌(STIC),这是推定的高恶性肿瘤的前兆

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Jennifer Kehlet Barton其他文献

Jennifer Kehlet Barton的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Jennifer Kehlet Barton', 18)}}的其他基金

Ovarian Cancer Detection with Blood- and Imaging-Based Biomarkers
使用基于血液和成像的生物标志物检测卵巢癌
  • 批准号:
    10598251
  • 财政年份:
    2022
  • 资助金额:
    $ 33.44万
  • 项目类别:
Ovarian Cancer Detection with Blood- and Imaging-Based Biomarkers
使用基于血液和成像的生物标志物检测卵巢癌
  • 批准号:
    10737827
  • 财政年份:
    2022
  • 资助金额:
    $ 33.44万
  • 项目类别:
Ovarian Cancer Detection with Blood- and Imaging-Based Biomarkers
使用基于血液和成像的生物标志物检测卵巢癌
  • 批准号:
    10544781
  • 财政年份:
    2022
  • 资助金额:
    $ 33.44万
  • 项目类别:
Ovarian Cancer Detection with Blood- and Imaging-Based Biomarkers
使用基于血液和成像的生物标志物检测卵巢癌
  • 批准号:
    10314537
  • 财政年份:
    2022
  • 资助金额:
    $ 33.44万
  • 项目类别:
Program 2: Cancer Imaging Program (CIP)
项目 2:癌症影像项目 (CIP)
  • 批准号:
    9315739
  • 财政年份:
    2017
  • 资助金额:
    $ 33.44万
  • 项目类别:
Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes
用于输卵管微创成像的先进输卵管镜
  • 批准号:
    9754821
  • 财政年份:
    2016
  • 资助金额:
    $ 33.44万
  • 项目类别:
Advanced Salpingoscope for Minimally-Invasive Imaging of the Fallopian Tubes
用于输卵管微创成像的先进输卵管镜
  • 批准号:
    9175237
  • 财政年份:
    2016
  • 资助金额:
    $ 33.44万
  • 项目类别:
Validating a mouse model of ovarian cancer for early detection through imaging
验证卵巢癌小鼠模型以通过成像进行早期检测
  • 批准号:
    8902450
  • 财政年份:
    2015
  • 资助金额:
    $ 33.44万
  • 项目类别:
Team-Based Design of Biomedical Devices
生物医学设备的团队设计
  • 批准号:
    8718794
  • 财政年份:
    2011
  • 资助金额:
    $ 33.44万
  • 项目类别:
Team-Based Design of Biomedical Devices
生物医学设备的团队设计
  • 批准号:
    8233281
  • 财政年份:
    2011
  • 资助金额:
    $ 33.44万
  • 项目类别:

相似海外基金

卵巣癌/子宮体癌における薬剤感受性メチル化診断キットの開発とLiquid Biopsyへの応用
卵巢癌/子宫内膜癌药物敏感甲基化诊断试剂盒的研制及其在液体活检中的应用
  • 批准号:
    24K02584
  • 财政年份:
    2024
  • 资助金额:
    $ 33.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
グリオーマのliquid biopsyによるメチル化網羅的解析とprecision medicineへの応用
胶质瘤液体活检甲基化综合分析及其在精准医疗中的应用
  • 批准号:
    24K12271
  • 财政年份:
    2024
  • 资助金额:
    $ 33.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Liquid biopsyを用いた炎症性腸疾患の早期診断法開発
液体活检炎症性肠病早期诊断方法的开发
  • 批准号:
    24K10595
  • 财政年份:
    2024
  • 资助金额:
    $ 33.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
精神的長期ストレス児童の口腔細菌叢と唾液成分の解析:唾液 liquid biopsyを目指して
长期精神应激儿童口腔菌群和唾液成分分析:唾液液体活检
  • 批准号:
    24K13206
  • 财政年份:
    2024
  • 资助金额:
    $ 33.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
MONALISA: A SIOPEN pragmatic clinical trial to MOnitor NeuroblastomA relapse with LIquid biopsy Sensitive Analysis
MONALISA:一项 SIOPEN 实用临床试验,通过液体活检监测神经母细胞瘤复发 敏感性分析
  • 批准号:
    10103126
  • 财政年份:
    2024
  • 资助金额:
    $ 33.44万
  • 项目类别:
    EU-Funded
A SIOPEN pragmatic clinical trial to MOnitor NeuroblastomA relapse with LIquid biopsy Sensitive Analysis (MONALISA)
SIOPEN 通过液体活检敏感性分析 (MONALISA) 监测神经母细胞瘤复发的实用临床试验
  • 批准号:
    10110442
  • 财政年份:
    2024
  • 资助金额:
    $ 33.44万
  • 项目类别:
    EU-Funded
Mutated human oncogene recombinant nucleosomes as reference materials for liquid biopsy
突变人癌基因重组核小体作为液体活检参考材料
  • 批准号:
    10090714
  • 财政年份:
    2024
  • 资助金额:
    $ 33.44万
  • 项目类别:
    Collaborative R&D
肝細胞癌における術中門脈血を用いたliquid biopsyの検討
肝细胞癌术中门静脉血液体活检检查
  • 批准号:
    24K19404
  • 财政年份:
    2024
  • 资助金额:
    $ 33.44万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Genetic diagnosis of vascular malformations by liquid biopsy and its application to precision medicine
液体活检对血管畸形的基因诊断及其在精准医疗中的应用
  • 批准号:
    23K09072
  • 财政年份:
    2023
  • 资助金额:
    $ 33.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Breath biopsy technology targeting for volatile oxidized lipids
针对挥发性氧化脂质的呼吸活检技术
  • 批准号:
    23K06080
  • 财政年份:
    2023
  • 资助金额:
    $ 33.44万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了