权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Manufacturing Green Nanoparticles for Efficient Cell Manufacture

制造绿色纳米粒子以实现高效的细胞制造

基本信息

批准号：
EP/L017059/1
负责人：
Karen Johnston
金额：
$ 19.6万
依托单位：
University of Strathclyde
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2014
资助国家：
英国
起止时间：
2014 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FL017059%2F1
关键词：
Manufacturing Green Nanoparticles Efficient Cell

项目摘要

Material-cell interface, which strongly depends on surface and materials properties, can augment cell growth and is extremely useful in enabling exquisite control of cellular manufacturing. We will address challenges related to the total efficiency of the cell production process starting with nature-inspired manufacture of bespoke green nanomaterials (GN), characterizing these nanoparticles, and evaluating how these materials affect the subsequent cell manufacture. As part of this call, we seek limited proof-of-concept funding 2 years. In order to manufacture green nanomaterials for efficient cell manufacture, there are following challenges:- Can we scale up green nanomaterial manufacture so as to be competitive?- How can we control flow to control manufacturing?- Can we showcase the application of green silicas for cell manufacture?- What nanoscale properties make green silicas superior?We will address these challenges from a unique perspective by collaborating across non-traditional disciplines involving nanomaterials chemistry, fluid dynamics, cell manufacturing and nanotechnology, and combining expertise from two EPSRC Centres for Innovative Manufacturing and two EPSRC Manufacturing Fellows. We have shown that GN, which provide an environmentally friendly approach, are scalable and have promising biomedical applications, while establishing the importance of mixing in nanomaterials scale-up operations. We have also identified strategies to efficient and automated cell manufacturing and developed nano-probes to extensively investigate surfaces and interfaces at the nanoscale. In this project, we aim to build on this success and go significantly beyond to address a number of key challenges to deliver large scale manufacturing of green nanomaterials suitable for cellular manufacture.

材料-细胞界面强烈依赖于表面和材料性质，可以促进细胞生长，并且在实现细胞制造的精细控制方面非常有用。我们将解决与细胞生产过程的总效率相关的挑战，首先是定制绿色纳米材料（GN）的自然灵感制造，表征这些纳米颗粒，并评估这些材料如何影响随后的细胞制造。作为此次电话会议的一部分，我们寻求2年的有限概念验证资金。为了制造用于高效电池制造的绿色纳米材料，存在以下挑战：-我们能否扩大绿色纳米材料制造以具有竞争力？-我们如何通过控制流程来控制生产？我们能展示绿色二氧化硅在电池制造中的应用吗？什么样的纳米级特性使绿色二氧化硅具有优越的上级性能？我们将从一个独特的角度来应对这些挑战，通过跨非传统学科合作，涉及纳米材料化学，流体动力学，细胞制造和纳米技术，并结合来自两个EPSRC中心的专业知识创新制造和两个EPSRC制造研究员。我们已经证明，GN提供了一种环境友好的方法，是可扩展的，并具有很好的生物医学应用，同时建立了混合纳米材料放大操作的重要性。我们还确定了高效和自动化细胞制造的策略，并开发了纳米探针，以广泛研究纳米级的表面和界面。在这个项目中，我们的目标是建立在这一成功的基础上，并大大超越，以解决一些关键的挑战，以提供大规模制造适用于细胞制造的绿色纳米材料。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Preparation of Functional Silica Using a Bioinspired Method.

使用仿生方法制备功能二氧化硅。

DOI：
10.3791/57730
发表时间：
2018-08-01
期刊：
Journal of visualized experiments : JoVE
影响因子：
0
作者：
Manning JRH;Routoula E;Patwardhan SV
通讯作者：
Patwardhan SV

The role of charge-matching in nanoporous materials formation

DOI：
10.1039/c8mh01640b
发表时间：
2019-06-01
期刊：
MATERIALS HORIZONS
影响因子：
13.3
作者：
Centi, Alessia;Manning, Joseph R. H.;Jorge, Miguel
通讯作者：
Jorge, Miguel

A feasibility study of the biologically inspired green manufacturing of precipitated silica

DOI：
10.1016/j.cej.2014.01.071
发表时间：
2014-05-15
期刊：
CHEMICAL ENGINEERING JOURNAL
影响因子：
15.1
作者：
Drummond, Craig;McCann, Rachelle;Patwardhan, Siddharth V.
通讯作者：
Patwardhan, Siddharth V.

Green Manufacturing of Functional Nanomaterials: case study of silica

功能纳米材料的绿色制造：二氧化硅案例研究

DOI：
发表时间：
2014
期刊：
影响因子：
0
作者：
Joseph Manning
通讯作者：
Joseph Manning

A Novel Method for Understanding the Mixing Mechanisms to Enable Sustainable Manufacturing of Bioinspired Silica.

DOI：
10.1021/acsengineeringau.2c00028
发表时间：
2023-02-15
期刊：
ACS ENGINEERING AU
影响因子：
0
作者：
Baba, Yahaya D;Chiacchia, Mauro;Patwardhan, Siddharth V
通讯作者：
Patwardhan, Siddharth V

DOI：
{{ item.doi }}
发表时间：
{{ item.publish_year }}
期刊：
{{ item.journal_name }}
影响因子：
{{ item.factor }}
作者：
{{ item.authors }}
通讯作者：
{{ item.author }}

数据更新时间：{{ journalArticles.updateTime }}

作者：
{{ item.author }}

数据更新时间：{{ monograph.updateTime }}

作者：
{{ item.author }}

数据更新时间：{{ sciAawards.updateTime }}

作者：
{{ item.author }}

数据更新时间：{{ conferencePapers.updateTime }}

作者：
{{ item.author }}

数据更新时间：{{ patent.updateTime }}

Karen Johnston其他文献

Apixaban to Prevent Recurrence After Cryptogenic Stroke in Patients With Atrial Cardiopathy: The ARCADIA Randomized Clinical Trial.

阿哌沙班预防心房性心脏病患者隐源性中风复发：ARCADIA 随机临床试验。

DOI：
发表时间：
2024
期刊：
Journal of the American Medical Association (JAMA)
影响因子：
0
作者：
Hooman Kamel;W. Longstreth;D. Tirschwell;R. Kronmal;R. Marshall;Joseph Broderick;R. Aragón García;P. Plummer;Noor Sabagha;Qi Pauls;C. Cassarly;Catherine R Dillon;Marco R. Di Tullio;E. Hod;E. Soliman;David J. Gladstone;Jeffrey S Healey;Mukul Sharma;Seemant Chaturvedi;L. S. Janis;Balaji Krishnaiah;Fadi Nahab;Scott E. Kasner;Robert J. Stanton;Dawn O. Kleindorfer;Matthew Starr;Toni R. Winder;Wayne M. Clark;Benjamin Miller;Mitchell S. V. Elkind;Ganesh Asaithambi;Maxwell Klaiman;Konark Malhotra;Mary Fetter;Anna Wanahita;Stacie Merritt;Rehan Sajjad;Kate McPolin;Bruce Coull;Shriya Kavathia;Murali Kolikonda;Sara Calhoun;Felipe De Los Rios La Rosa;Ian Del Conde;Josette Elysée;A. Aghaebrahim;Melissa Stratoberdha;Andria Ford;James Giles;Yan Wang;Jennifer Babka;Rahul Damani;Barbara Gutierrez;Sandeep Kumar;Sarah Marchina;Marc Swerdloff;Margaret Scott;Amandeep Sangha;Kelly Patterson;Julie Shulman;Steven Feske;José Rafael Romero;Hugo Aparicio;David M. Greer;Rebecca Stafford;Arturo Tamayo;Leanne Anderson;S. Smirnakis;Quinn Rademaker;Maurice Hourihane;Robert N. Sawyer;Marilou I Ching;Amit Kandel;Rakesh Magun;Annemarie Crumlish;Annaliese Bosco;Sanjay Singh;Abhishek Singh;Elizabeth Traynor;Rammohan Sankaraneni;Toufik Haddad.;Carly Isder;Lois Rasmussen;Dustin Rochestie;Nancy Brunetti;Dhruvil Pandya;Rosemarie Baligod;Dan Capampangan;Allegra Sahelian;Jason Nomura;Kimberly Gannon;Jonathan Raser;Kathleen Murphy;Ahmed Itrat;Debra Hudock;D. Wisco;Laura Sweeney;William Likosky;Rebekah Garcia;Hermann Schumacher;Lindsey Colman;Benjamin Lisle;Uriah Atkinson;Wady Aude;Cassandra Trevino;Kevin Attenhoffer;Claudia Fortiche;Kumar Rajamani;Amanda Reyes;Hasnain Arshad;Julie Weidman;Peter Adamczyk;Leah Galvez;Fadi Nahab;Michael Frankel;Alicia Escobar;Kiva Schindler;Megan Schultz;Lori Bhadsavle;Leah Craft;Ariane Mackey;S. Verreault;Marie;S. Gosselin;Suzy Lavoie;Nirav Patel;Richard Bailey;Marc Lazzaro;Marek Čierny;Ann Helms;Caitlin Moore;Diane Book;Hatim Attar;Tiffany Morse;Sophia Aboagye;Lakiesha Coleman;Katie Alter;Rodney Short;Desyree Weakley;Jana Wold;Kinga Aitken;Harmeet Sachdev;Audrey Paulson;Nicolas Bianchi;Kelvin Ng;K. Ratnayake;D. Tirschwell;Mary Asirot;Allison Kunze;Yan Hou;Reena Patel;Laura Greiner;Benjamin Miller;J. Scherber;A. Katramados;Teresa Wiegand;Scott E. Kasner;Rebecca Burdett;Brett Cucchiara;Steven Messe;Qingyang Yuan;Donna Kurowski George;J. Witsch;Laura Stein;Christopher Favilla;James Siegler;Jesse Thon;Michael Mullen;Aaron Rothstein;Ossama Khaazal;Daniel Cristancho;Emily Grodinsky;Farhan Khan;Christopher Renner;Jonah Zuflacht;Kelley A. Humbert;Aroosh Kumar;Judy Dawod;Gbambele Kone;Sahily Reyes;Nino Kvantaliani;Mary Liz De Santo;Nichole Gallatti;Devin Keating;Mauricio Concha;Robynn Pannell;N. Murray;Jacki Anderson;Lindsay Bosh;Erika Marulanda;Andrea Escobar;Z. Ajani;Nathalie Gonzalez;William Neil;Michael Fechter;N. Sanossian;Jesus Pena;Clare Binley;E. Elamin;Meghan Gerein;Susan Law;Monique Tita;S. Jalini;Andrew Nguyen;Siddharth Sehgal;Collin Culbertson;Penhleakhena Ou;Kaitlyn Kirchhoffer;Danielle Cross;Louise Kruse;Martin Gizzi;Karla Kummer;Hussam Yacoub;Andrew Orzel;Salman Azhar;Ronnie Elsaadany;L. Sposato;J. Mandzia;L. Mai;Alexander Khaw;S. Fridman;B. Beauchamp;L. Lambourn;Nima Ramezan;Deysi Caballero;Omid Omidvar;Michael Thompson;Melanie Altamirano;Svetlana Pundik;Manda Double;O. Bentho;Christopher Streib;Muhammad Affan;Haitham Hussein;Margy E. McCullough;Praveen Hariharan;Amelia Solei;Kate Bard;Amanda Weller;Kathleen Miller;Anna Brauch;Chloe Lawyer;Deb Quigley;Abbey Staugaitis;Qingliang Wang;Maryna Mootoo;Aneesh B Singhal;Rhianna Carr;Alejandro Rabinstein;Eugene Scharf;Amy Headlee;Michelle Lin;Meredith McDonald;Taylor Reid;A. Majjhoo;Roberts Marci;Mahmoud Rayes;Emily Paschall;Karl Meisel;Colleen Shaw;Andrew Stemer;Emma Waldon;A. Hsia;Chandni Kalaria;Shannon P. Burton;Yongwoo Kim;Sana Somani;Veronica Craft;Jamal Smith;Juby Matthews;Megan Grainger;Cassidy Anderson;Christine Holmstedt;Caitlan Lematty;A. Sharrief;Gabretta Cooksey;Yazan Alderazi;Chad Tremont;L. Maidan;Danielle Hornbuckle;Osama O. Zaidat;Cynthia Upham;Balaji Krishnaiah;Andrei Alexandrov;C. Elangovan;Mark Rubin;Quentin Thacker;Joseph Hanna;Dana Cook;Bradley Jacobs;Christina Weller;Kathryn Kirchoff;Mellanie Springer;Khadean Moncrieffe;Tanzina Islam;Pramod Sethi;Jamil Ahmed;Steven Rudolph;Holly Morhaim;C. Brockington;Naresh Poondla;Calvin Hansen;Heather Banker;Imama Naqvi;Eliza Miller;Carmen Castillo;R. Aragón García;Kevin Slane;Neal Parikh;Babak Navi;Saad Mir;Alan Segal;Halina White;Ava Liberman;Dana Leifer;Hooman Kamel;Carla Sherman;Jed H. Kaiser;Vanessa Liao;Natalie M LeMoss;Kelsey Lansdale;Aaron Lord;Maria Cotrina;Jose Torres;Danika Anganoo;Toni R. Winder;J. Elliot;Yahya Atalay;Courtney Stathis;Jeffrey Katz;Erin Schwartz;Kayla Stanton;Sandra Anghel;Ahmad Ballout;Alicia Dee;Morteza Modaber;Neisha Patel;Rohan Arora;Ina Teron;Richard Libman;Kirendra Pasram;Fan Caprio;Rachel Vincent;Arun Talkad;Ashwath Ravisankar;Alicia Zha;Mohammad Hamed;Evgeny Sidorov;Danny Samkutty;David Gordon;Robert Hamilton;Faddi Velez;Jason King;Bappaditya Ray;April Vaughn;Blair Hill;Jason Sharps;Richard Zweifler;Jessica Henry;Wayne M. Clark;H. Bozorgchami;Parker Miller;Rachel Laursen;Sonesh Amin;Megan Pattle;Jon Foley;Monica Dolan;Emilie Nagle;Paulo Zortea;Reilly Leonard;Souvik Sen;Nishanth Kodumuri;Justin Lowe;M. Logue;Amanda Kabetso;Phil Fleming;Corey White;Damon Gates;A. Towfighi;M. Ayala;Raul Guisado;Karen De La Cuest;Maria Pyle;Tina M Burton;Karen L Furie;S. Yaghi;Narendra S Kala;Ashley Schomer;Scott Moody;Deepica Chaudhry;Catrina Elizardo;Nirav Vora;Katy Groezinger;Deviyani Mehta;Michelle Moccio;Edward Stenroos;J. Saver;Daisy Mercado;Brett Graham;Gary Hunter;L. Peeling;Michael Kelly;R. Cooley;S. Wasyliw;C. Tyson;E. Junk;K. Foster;K. Bolt;L. Urroz;R. Whelan;A. Gardner;Shrijal Bhavsar;Laurel Cherian;James Conners;Sarah Song;Rima M. Dafer;Alejandro Vargas;Henna McCoy;Karin Olds;Debbie Summers;Rene Colorado;Terri Nielsen;Juan Morales;Claude Hemphill;Dominica Randazzo;Destini Spaeth;Jason Neal;Melissa Zdroik;R. Modir;Theresa Mcquaid;Yu Cheng;C. Murphy;Henrik Manassarians;Fazeel Siddiqui;Laura Reiser;Muhib Khan;Heidi Taylor;Stephanie Mueller;Naim Khoury;Lauren Bainter;Supreet Kaur;Guadalupe Calzadillas;R. Edgell;Benjamin Cummins;Logan McDaneld;Lisa Bertrand;Kelly Matmati;Nabil Matmati;Nirali Vora;Madelleine Garcia;David Spence;Tisha Mabb;Curtis Benesch;Emily Prentiss;J. Hopyan;David J. Gladstone;I. Fatakdawala;Manoj K. Mittal;Tammy Donnel;Dawn Lenakakis;Katharyn Gelinas;Alicia Bennett;W. Burgin;Marla Hairston;Paul Katz;Hannah Reimer;Rony Salem;Tracy Stern;Robin Dharia;Sasha Paglione;Christopher Goshgarian;Stacy Smith;Emiliya Melkumova;Nikolas Melkumyan;S. Onteddu;Lisa Richardson;M. Shafie;Wengui Yu;Julia Fong;Josue Prado;Karen Rapp;Wade Smith;Christina Wilson;Neringa May;S. Sundararajan;Mary Andrews;R. Goddeau;Brian Silver;Christina Manxhari;Meaghan Demers;Cynthia Kenmuir;Kristen Kerfoot;Christy Ireland;Matthew Starr;Ty Shang;Mark Johnson;Erica Jones;Mehari Gebreyohannas;Jessica Clark;Andrew Southerlandc;Bradford Worrallc;Matthew Gusler;Keri JohnsonN;Necrisha Roach;Sherita Chapman;Nina Solenski;Rohini Bhole;Amna Sohail;Karen Johnston;Andrew Weko;Miah Perch;Cheyenne Batton;Allison Ramsey;Sonya Gunter;Jane E Monita;Marie Meyer;Jennifer Murwin;Kaitlin A. Lundell;Nimco Essa;Michael Lyerly;Tammy Davis;Ashfaq Shuaib;L. Piquette;Michael Hill;S. Coutts;Supriya Save;Karla J. Ryckborst;C. Kenney;Lana Toussaint;J. Brorson;E. Coleman;Emma Hall;Robert J. Stanton;Dawn O. Kleindorfer;S. Demel;Jennifer Powers;F. Testai;Maureen Hillmann;Enrique C Leira;Heena M. Olalde;Jorge Kawano;Aparna Pendurthi;Margaret Houghton;Justin Moore;Joel Maruthanal;Alissa Fugate;Saurav Das;Creed L. Pettigrew;Pattricia Arnold;Tracy Ander;Ann Jerde;Seemant Chaturvedi;Christina Spadafora;Joseph Carrera;Christopher Becker;Devin Brown;James Burke;Frank Conyers;Anthony Harrington;Christopher Hill;Jessica Roberts;Patty Johnson;Shashank Shekhar;S. Gangadhara;Margaret Smith;Pierre Fayad;Helen Obaro;Tarun Girotra;Jacqueline Morales;Erin Rael;Muhammad;Rebecca Sugg;Tamekia Grissett;Stefanie White;Reza Behrouz;Jody Richardson;Lee Chung;J. Majersik;Dana DeWitt;Stephanie Lyden;Vivek Reddy;Peter Tekiela;Peter Hannon;Adam de Havenon;Brian Marcus;Knut Hoversten;Chelsea Meyer;Jerdan Ruff;Theodore Rock;Michael Dela Cruz;Edward Bradbury;Jenna Bock;Kevin Call;Ryan McQuivey;Karen Belanger;Andrew A. Huffer;Sharon McRae;Ameer E Hassan;Raza Khan;Olive Sanchez;Thalia S Field;Laura Wilson;J. Gorman;Stephen Van Gaal;S. Yip;P. Teal;Oscar R. Benavente;S. Mann;P. King;G. Maclean;Carson Ma;K. Villaluna;Michael T. Froehler;Hemangi Rajpal;Muhammad Alvi;Sara Dobrzynski;Jay Sherman;Cheryl Bushnell;Krystal Schmidt;Roi Wallis;Kimberly Panizzon;Reshma Narula;L. Kuohn;Sara Jasak;Michael C Kampp;Melissa Pish
通讯作者：
Melissa Pish

Parent Satisfaction With Pediatric Nurse Practitioner Care in Specialty Services.

家长对专业服务中儿科执业护士护理的满意度。

DOI：
发表时间：
2022
期刊：
Journal of Pediatric Health Care
影响因子：
2.8
作者：
B. Thibodeau;S. Hryniuk;W. Beaudoin;L. Jurasek;Shirley Perry;Tamara Dorfman;Jolene Issel;Karen Johnston;Deborah Olmstead
通讯作者：
Deborah Olmstead