Manufacturing Green Nanoparticles for Efficient Cell Manufacture

材料-细胞界面强烈依赖于表面和材料性质，可以促进细胞生长，并且在实现细胞制造的精细控制方面非常有用。我们将解决与细胞生产过程的总效率相关的挑战，首先是定制绿色纳米材料（GN）的自然灵感制造，表征这些纳米颗粒，并评估这些材料如何影响随后的细胞制造。作为此次电话会议的一部分，我们寻求2年的有限概念验证资金。 为了制造用于高效电池制造的绿色纳米材料，存在以下挑战：-我们能否扩大绿色纳米材料制造以具有竞争力？-我们如何通过控制流程来控制生产？我们能展示绿色二氧化硅在电池制造中的应用吗？什么样的纳米级特性使绿色二氧化硅具有优越的上级性能？我们将从一个独特的角度来应对这些挑战，通过跨非传统学科合作，涉及纳米材料化学，流体动力学，细胞制造和纳米技术，并结合来自两个EPSRC中心的专业知识创新制造和两个EPSRC制造研究员。 我们已经证明，GN提供了一种环保方法，具有可扩展性，并且具有广阔的生物医学应用前景，同时确立了混合在纳米材料放大操作中的重要性。我们还确定了高效和自动化细胞制造的策略，并开发了纳米探针，以广泛研究纳米级的表面和界面。在这个项目中，我们的目标是建立在这一成功的基础上，并大大超越，以解决一些关键的挑战，以提供大规模制造适用于细胞制造的绿色纳米材料。

Material-cell interface, which strongly depends on surface and materials properties, can augment cell growth and is extremely useful in enabling exquisite control of cellular manufacturing. We will address challenges related to the total efficiency of the cell production process starting with nature-inspired manufacture of bespoke green nanomaterials (GN), characterizing these nanoparticles, and evaluating how these materials affect the subsequent cell manufacture. As part of this call, we seek limited proof-of-concept funding 2 years. In order to manufacture green nanomaterials for efficient cell manufacture, there are following challenges:- Can we scale up green nanomaterial manufacture so as to be competitive?- How can we control flow to control manufacturing?- Can we showcase the application of green silicas for cell manufacture?- What nanoscale properties make green silicas superior?We will address these challenges from a unique perspective by collaborating across non-traditional disciplines involving nanomaterials chemistry, fluid dynamics, cell manufacturing and nanotechnology, and combining expertise from two EPSRC Centres for Innovative Manufacturing and two EPSRC Manufacturing Fellows. We have shown that GN, which provide an environmentally friendly approach, are scalable and have promising biomedical applications, while establishing the importance of mixing in nanomaterials scale-up operations. We have also identified strategies to efficient and automated cell manufacturing and developed nano-probes to extensively investigate surfaces and interfaces at the nanoscale. In this project, we aim to build on this success and go significantly beyond to address a number of key challenges to deliver large scale manufacturing of green nanomaterials suitable for cellular manufacture.