Chondrocyte hypertrophy in development and disease

发育和疾病中的软骨细胞肥大

• 批准号: nhmrc : 607385
• 负责人: Prof Amanda Fosang
• 金额: $ 24.01万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/chondrocyte-hypertrophy-development-disease/96989
• 关键词: Chondrocyte; hypertrophy; development; disease

Whereas chondrocyte hypertrophy is a normal feature of skeletal growth, in adult chondrocytes it is associated with osteoarthritis (OA). We propose that collagen II fragments provide signals for hypertrophy in cartilage. The lack of collagen II fragments in our collagenase-resistant mouse provides a unique opportunity to address the role of collagen II fragments in driving cellular hypertrophy. We will identify bioactive collagen II fragments that represent novel targets for OA therapies

虽然软骨细胞肥大是骨骼生长的正常特征，但在成人软骨细胞中，它与骨关节炎(OA)有关。我们认为，II型胶原片段为软骨肥大提供了信号。在我们的胶原酶抗性小鼠中缺乏II型胶原片段，这为解决II型胶原片段在驱动细胞肥大中的作用提供了一个独特的机会。我们将鉴定具有生物活性的II型胶原片段，这些片段代表了OA治疗的新靶点。