Signalling through a bioactive aggrecan fragment: what is the mechanism?

通过生物活性聚集蛋白聚糖片段发出信号：机制是什么？

• 批准号: nhmrc : 1060222
• 负责人: Prof Amanda Fosang
• 金额: $ 28.76万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/signalling-bioactive-aggrecan-fragment-mechanism/454809
• 关键词: Signalling; through; bioactive; aggrecan; fragment

Osteoarthritis (OA) affects approximately 20% of Australians. There are no therapies that modify the course of the disease and joint replacement surgery is expensive and invasive. We have discovered that a peptide product of cartilage breakdown (the 32mer) signals cartilage cells to mount an inflammatory and catabolic response. We will determine how the 32mer triggers this response, whether other joint cells are similarly activated and how it can be stopped, with the goal of pursuing new targets for therapy

骨关节炎(OA)影响大约20%的澳大利亚人。目前还没有改变病程的治疗方法，关节置换手术昂贵且具有侵入性。我们已经发现，软骨分解的一种多肽产物(32mer)向软骨细胞发出信号，使其产生炎症和分解代谢反应。我们将确定32mer如何触发这种反应，其他关节细胞是否也同样被激活，以及如何阻止它，目标是为治疗寻找新的靶点。