Vanin-3 signalling in osteoarthritis

骨关节炎中的 Vanin-3 信号传导

• 批准号: nhmrc : GNT1060576
• 负责人: Prof Amanda Fosang
• 金额: $ 63.04万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/vanin-3-signalling-osteoarthritis/1344736
• 关键词: Vanin; signalling; osteoarthritis

Osteoarthritis (OA) affects approximately 20% of Australians and costs billions each year in joint replacements. Therapies that halt joint destruction in OA are urgently needed. We hypothesise that the little-known gene, vanin -3, is a key regulator of OA disease pathways. Our project will map vanin-3 in the joint and reveal how much vanin-3 contributes to joint destruction in mice. We expect to find a link between vanin-3 and metabolic disorders and identify new targets for therapy.

骨关节炎（OA）影响了大约20%的澳大利亚人，每年花费数十亿美元进行关节置换。迫切需要阻止OA关节破坏的治疗方法。我们假设鲜为人知的基因vanin-3是OA疾病通路的关键调节因子。我们的项目将绘制关节中的vanin-3，并揭示vanin-3对小鼠关节破坏的贡献。我们希望找到vanin-3和代谢紊乱之间的联系，并确定新的治疗靶点。