Angiogenic defects in mutant growth plate cartilage reveal new modulators of vascular invasion

突变生长板软骨的血管生成缺陷揭示了血管侵袭的新调节因子

• 批准号: DP130104083
• 负责人: Prof Amanda Fosang
• 金额: $ 25.15万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP130104083
• 关键词: Angiogenic; defects; mutant; growth; plate

Converting cartilage to bone requires blood vessel invasion from the bony interface. This project will test, in vitro and in vivo, the hypothesis that collagen fragments regulate blood vessel invasion into cartilage. This data will have implications for processes requiring new blood vessels such as bone growth, cancer, inflammation and ischemia.

将软骨转化为骨需要从骨界面侵入血管。该项目将在体外和体内测试胶原片段调节血管侵入软骨的假设。这些数据将对需要新血管的过程产生影响，如骨生长，癌症，炎症和缺血。