Scale-up of solvent-free synthesis

无溶剂合成的放大

• 批准号: EP/L019655/1
• 负责人: S James
• 金额: $ 57.44万
• 依托单位: Queen's University Belfast
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FL019655%2F1
• 关键词: Scale; up; solvent; free; synthesis

Solvents are traditionally assumed to be essential for most chemical reactions to proceed at an acceptable rate and in a controlled way. They are correspondingly ubiquitous in chemical processes, but simultaneously generate enormous amounts of waste, deplete fossil resources and require large amounts of energy to produce, purify and recycle. Finding cleaner and more sustainable ways of manufacturing chemicals and materials is a priority goal globally for the foreseeable future. Therefore, innovative thinking to come up with new types of processes which do not need solvents, and which can be scaled up to industrial production levels, is now critically important. 'Mechanochemistry' is a way of inducing chemical reactions simply by grinding solids together, and it is now attracting attention as an alternative general approach to traditional solvent-intensive methods. It has recently emerged that by using surprisingly simple, energy-efficient grinding apparatus such as ball mills, many reactions between solids can actually be performed, at least on small scales, oftenwithin a few minutes and without any added solvent. However, a critical issue now is how to scale-up this mechanochemical synthesis to industrially-applicable levels. This project aims to provide a step-change in this area by enabling such chemistry to be done on larger scales so making it more applicable to industrial implementation. This project is highly interdisciplinary, bringing together experts in chemistry, chemical engineering, mechanical engineering and pharmaceutical processing. The project is structured in order to: 1) gain greater knowledge and understanding of how such chemistry works and thus how to optimise it, and 2) explore how it can be used to provide new types of chemical reactions and chemistry and processes. A recently-formed university spin-out company will act a vehicle to maximise the commercial impact of this research.

传统上认为，要使大多数化学反应以可接受的速度和受控的方式进行，溶剂是必不可少的。相应地，它们在化学过程中无处不在，但同时会产生大量废物，消耗化石资源，并需要大量能源来生产、净化和回收。在可预见的未来，找到更清洁、更可持续的化学品和材料制造方法是全球的优先目标。因此，创新思维，提出不需要溶剂的新型工艺，并且可以扩大到工业生产水平，现在至关重要。机械力化学是一种简单地通过将固体研磨在一起来引发化学反应的方法，作为传统的溶剂密集型方法的替代方法，它现在正引起人们的注意。最近发现，通过使用球磨机等极其简单、节能的研磨设备，固体之间的许多反应实际上都可以进行，至少在小范围内进行，通常在几分钟内完成，而且不需要添加任何溶剂。然而，现在的一个关键问题是如何将这种机械力化学合成放大到工业应用的水平。该项目旨在通过使这种化学能够在更大的规模上进行，从而使其更适用于工业实施，从而在这一领域提供一个阶段性的变化。这个项目是高度跨学科的，汇集了化学、化学工程、机械工程和制药工艺方面的专家。该项目的结构是为了：1)更多地了解和理解这种化学是如何工作的，从而如何优化它，以及2)探索如何使用它来提供新型的化学反应和化学和过程。最近成立的一家大学衍生公司将作为一种工具，最大化这项研究的商业影响。

项目成果

Organic synthesis by Twin Screw Extrusion (TSE): continuous, scalable and solvent-free

• DOI: 10.1039/c6gc03413f
• 发表时间: 2017-03-21
• 期刊: GREEN CHEMISTRY
• 影响因子: 9.8
• 作者: Crawford, Deborah E.;Miskimmin, Clodagh K. G.;James, Stuart L.
• 通讯作者: James, Stuart L.

Efficient continuous synthesis of high purity deep eutectic solvents by twin screw extrusion

• DOI: 10.1039/c5cc09685e
• 发表时间: 2016-01-01
• 期刊: CHEMICAL COMMUNICATIONS
• 影响因子: 4.9
• 作者: Crawford, D. E.;Wright, L. A.;Abbott, A. P.
• 通讯作者: Abbott, A. P.

Synthesis by extrusion: continuous, large-scale preparation of MOFs using little or no solvent.

• DOI: 10.1039/c4sc03217a
• 发表时间: 2015-03-01
• 期刊: Chemical science
• 影响因子: 8.4
• 作者: Crawford D;Casaban J;Haydon R;Giri N;McNally T;James SL
• 通讯作者: James SL

Papain-catalysed mechanochemical synthesis of oligopeptides by milling and twin-screw extrusion:

通过研磨和双螺杆挤出，木瓜蛋白酶催化机械化学合成寡肽：

• 发表时间: 2018
• 期刊: Green Chemistry
• 影响因子: 9.8
• 作者: Ardila-Fierro KJ

Translating solid state organic synthesis from a mixer mill to a continuous twin screw extruder

• DOI: 10.1039/c8gc02036a
• 发表时间: 2018-09-07
• 期刊: GREEN CHEMISTRY
• 影响因子: 9.8
• 作者: Cao, Qun;Howard, Joseph L.;Browne, Duncan L.
• 通讯作者: Browne, Duncan L.