Chronic active viral persistence versus host immune mediated pathology: an analysis and manipulation of the balance.

慢性活性病毒持久性与宿主免疫介导的病理学：平衡的分析和操纵。

• 批准号: nhmrc : 1006592
• 负责人: Prof Marc Pellegrini
• 金额: $ 27.92万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/chronic-active-viral-manipulation-balance/109198
• 关键词: Chronic; active; viral; persistence; versus

Our robust ability to mount an immune response and clear infections is tempered by the possibility of promoting autoimmunity. Several host genes regulate immunity. Viruses like HIV have exploited these to abrogate antiviral immunity. This project attempts to define host factors that promote chronic infection. This will be extremely valuable in understanding the vulnerabilities of our immune system and provide an insight into how we can treat chronic infections.

我们发动免疫反应和清除感染的强大能力受到促进自身免疫的可能性的影响。几种宿主基因调节免疫力。像艾滋病毒这样的病毒已经利用这些来消除抗病毒免疫力。本项目试图确定促进慢性感染的宿主因素。这对于了解我们免疫系统的脆弱性非常有价值，并为我们如何治疗慢性感染提供了见解。