Understanding the role of host Arih2 in defence against viral infection and disease pathogenesis

了解宿主 Arih2 在防御病毒感染和疾病发病机制中的作用

• 批准号: nhmrc : 1045532
• 负责人: Prof Marc Pellegrini
• 金额: $ 35.86万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-role-host-disease-pathogenesis/111762
• 关键词: Understanding; role; host; Arih2; defence

A set of proteins, called E3 ligases, modulate many aspects of immunity. Arih 2 is a novel E3 ligase that limits immune cell activation to maintain the immune system in a quiescent state. The details of how Arih2 functions and its role in immunity to chronic overwhelming infection are the focus of this study. The insights gained from these studies have important implications for our understanding of how immune responses can be promoted during infection or halted in autoimmunity.

一组称为 E3 连接酶的蛋白质可调节免疫的许多方面。 Arih 2 是一种新型 E3 连接酶，可限制免疫细胞激活以维持免疫系统处于静止状态。 Arih2 的功能细节及其在慢性压倒性感染免疫中的作用是本研究的重点。从这些研究中获得的见解对于我们理解如何在感染期间促进免疫反应或在自身免疫中停止免疫反应具有重要意义。