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Understanding the role of host Arih2 in defence against viral infection and disease pathogenesis

Understanding the role of host Arih2 in defence against viral infection and disease pathogenesis
了解宿主 Arih2 在防御病毒感染和疾病发病机制中的作用
批准号：
nhmrc : 1045532
负责人：
Prof Marc Pellegrini
金额：
$35.86万
依托单位：
The Walter and Eliza Hall Institute of Medical Research
依托单位国家：
澳大利亚
项目类别：
Project Grants
财政年份：
2013
资助国家：
澳大利亚
项目状态：
已结题
起止时间：
2013-01-01 至 2015-12-31
来源：
https://researchdata.edu.au/understanding-role-host-disease-pathogenesis/111762
关键词：
UnderstandingrolehostArih2defence

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中文摘要
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英文摘要
A set of proteins, called E3 ligases, modulate many aspects of immunity. Arih 2 is a novel E3 ligase that limits immune cell activation to maintain the immune system in a quiescent state. The details of how Arih2 functions and its role in immunity to chronic overwhelming infection are the focus of this study. The insights gained from these studies have important implications for our understanding of how immune responses can be promoted during infection or halted in autoimmunity.
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