The role of Rip3 and caspase 8 in necroptosis and apoptosis during viral infection

Rip3和caspase 8在病毒感染过程中坏死性凋亡和细胞凋亡中的作用

• 批准号: nhmrc : 1045549
• 负责人: Prof Marc Pellegrini
• 金额: $ 30.64万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-rip3-caspase-viral-infection/111765
• 关键词: role; Rip3; caspase; necroptosis; apoptosis

Programmed cell death can be beneficial or detrimental depending on circumstances. This delicate balance is most obvious during an infection. The host tries to limit the spread of a pathogen by initiating programmed death in infected cells but excessive death particularly in uninfected cells is catastrophic. It is essential to have a thorough understanding of the interplay between cell death mechanisms so we can overt pathological outcomes and this is the focus of our research.

程序性细胞死亡可以是有益的或有害的，这取决于情况。这种微妙的平衡在感染期间最为明显。宿主试图通过启动受感染细胞的程序性死亡来限制病原体的传播，但过度死亡，特别是未感染细胞的过度死亡是灾难性的。深入了解细胞死亡机制之间的相互作用是至关重要的，因此我们可以公开病理结果，这是我们研究的重点。