The role of Rip3 and caspase 8 in necroptosis and apoptosis during viral infection

细胞程序性死亡可能是有益的，也可能是有害的，这取决于环境。这种微妙的平衡在感染期间最为明显。宿主试图通过在受感染的细胞中启动程序性死亡来限制病原体的传播，但过度死亡，特别是在未受感染的细胞中，是灾难性的。彻底了解细胞死亡机制之间的相互作用是至关重要的，这样我们才能公开病理结果，这也是我们研究的重点。

Programmed cell death can be beneficial or detrimental depending on circumstances. This delicate balance is most obvious during an infection. The host tries to limit the spread of a pathogen by initiating programmed death in infected cells but excessive death particularly in uninfected cells is catastrophic. It is essential to have a thorough understanding of the interplay between cell death mechanisms so we can overt pathological outcomes and this is the focus of our research.