Sponsorship Award. Cell-by-Cell: On Demand Assembly & Control of Microbial Communities for the Water Industry.

赞助奖。

• 批准号: EP/L026511/1
• 负责人: Ameet Pinto
• 金额: $ 2.57万
• 依托单位: University of Glasgow
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2014
• 资助国家: 英国
• 起止时间: 2014 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FL026511%2F1
• 关键词: Sponsorship; Award.; Cell; Demand; Assembly

The water industry has relied on consortia of diverse microorganisms to perform some of its most vital functions (e.g. wastewater treatment, biological drinking water treatment, renewable energy production). These microbial assemblages have provided us with technologies that have not only significantly improved our quality of life, but also reversed the rapid degradation of our environment. The assembly of these complex microbial communities has thus far been guided either by happenstance environmental conditions or through trial-and-error based engineering approaches that are largely top-down in nature. In keeping with this top-down assembly, the function of these communities is also controlled in bulk, such that large-scale environmental effects are engineered to stimulate or inhibit functions of entire groups of microorganisms (e.g. controlling the availability of electron acceptors such as oxygen). We are proposing the development of a new approach that does not rely on happenstance environmental condition or bulk control, but rather engineers the assembly and control of microbial communities from the bottom-up, i.e. on a cell-by-cell basis. Our confidence in this approach is inspired not only by the recent technological breakthroughs in 'omics technologies, synthetic biology and 3D printing; but also a deep respect for the evolutionary processes that have generated the microbial vastness and its metabolic potential around us. Through the EPSRC Sponsorship Award, we propose to catalyze research momentum within our home universities and the UK to start exploring how synthetic microbial community assembly may accomplish, how it may improve existing technologies, and deliver radical technological breakthroughs for the water industry. To do this, we have proposed a series of strategically timed activities (e.g. research visits, workshops, retreats) that will engage the core investigator team in this adventurous research theme by gaining new research expertise and connecting with a broad network of academic and industrial partners from the UK, Europe, and USA.

水工业依赖于不同微生物的联合体来执行其一些最重要的功能（例如废水处理，生物饮用水处理，可再生能源生产）。这些微生物组合为我们提供了技术，不仅大大提高了我们的生活质量，而且还扭转了我们环境的快速退化。迄今为止，这些复杂的微生物群落的组装要么由偶然的环境条件指导，要么通过基于试错的工程方法指导，这些方法在本质上主要是自上而下的。为了与这种自上而下的组装保持一致，这些群落的功能也被大量控制，使得大规模的环境效应被工程化以刺激或抑制整个微生物群体的功能（例如控制电子受体如氧气的可用性）。我们正在提出一种新方法的开发，该方法不依赖于偶然的环境条件或批量控制，而是自下而上，即逐个细胞地设计微生物群落的组装和控制。我们对这种方法的信心不仅来自于最近在“组学技术，合成生物学和3D打印”方面的技术突破，而且还来自于对进化过程的深深尊重，这些进化过程产生了我们周围的微生物及其代谢潜力。通过EPSRC赞助奖，我们建议在我们的国内大学和英国催化研究势头，开始探索合成微生物群落组装如何实现，如何改进现有技术，并为水行业带来根本性的技术突破。为此，我们提出了一系列具有战略意义的定时活动（例如研究访问，研讨会，务虚会），通过获得新的研究专业知识并与来自英国，欧洲和美国的广泛的学术和工业合作伙伴网络建立联系，使核心研究团队参与这一冒险的研究主题。

项目成果

Anaerobic microbial community response to methanogenic inhibitors 2-bromoethanesulfonate and propynoic acid.

• DOI: 10.1002/mbo3.349
• 发表时间: 2016-08
• 期刊: MicrobiologyOpen
• 影响因子: 3.4
• 作者: Webster TM;Smith AL;Reddy RR;Pinto AJ;Hayes KF;Raskin L
• 通讯作者: Raskin L

The anti-bat strategy of ultrasound absorption: the wings of nocturnal moths (Bombycoidea: Saturniidae) absorb more ultrasound than the wings of diurnal moths (Chalcosiinae: Zygaenoidea: Zygaenidae).

超声吸收的抗BAT策略：夜间飞蛾（Bombycoidea：Saturniidae）的翅膀比昼夜飞蛾（Chalcosiinae：Zygaenoidea：Zygaenidae）更吸收超声。

• DOI: 10.1242/bio.021782
• 发表时间: 2017-01-15
• 期刊: Biology open
• 影响因子: 2.4
• 作者: Ntelezos A;Guarato F;Windmill JF
• 通讯作者: Windmill JF

Draft Genome Sequence of a Novel Desulfobacteraceae Member from a Sulfate-Reducing Bioreactor Metagenome.

• DOI: 10.1128/genomea.01540-15
• 发表时间: 2016-01-14
• 期刊: Genome announcements
• 作者: Almstrand R;Pinto AJ;Figueroa LA;Sharp JO
• 通讯作者: Sharp JO

Draft Genome Sequences of Two Novel Acidimicrobiaceae Members from an Acid Mine Drainage Biofilm Metagenome.

• DOI: 10.1128/genomea.01563-15
• 发表时间: 2016-01-14
• 期刊: Genome announcements
• 作者: Pinto AJ;Sharp JO;Yoder MJ;Almstrand R
• 通讯作者: Almstrand R