Core Capability for Chemistry Research - Leeds

在我们投标书的A部分，利兹大学化学学院申请资金购买一台600 MHz NMR光谱仪、一台单晶XRD光谱仪和一台变压SEM。600 MHz NMR光谱仪将取代学校75%的教学人员使用的主要服务仪器。新仪器将具有低温和高温（可变）以及多核能力（包括11B），并用于更复杂的分析，包括选择性激发实验，更多的“外来”核检测，动力学研究，以及（非常）样本有限的数据收集。与现有仪器相比，它还将提供更高的分辨率，屏蔽（高冷冻剂保持时间）磁体和新探头将大大改善所有核的信噪比。光谱仪将主要用于提供学校服务，但与我们的旧仪器相比，其上级性能意味着该设施也可以向经验不足的用户开放，用于专业应用。新的单晶衍射仪系统将取代一个失败的10岁的仪器，并将支持该部门约50%的学术人员的工作，提供重要的结构测定。该仪器将配备一个具有双波长（Mo和Cu）能力的微焦点X射线源，沿着外围设备，如低温晶体冷却装置和用于原始数据存储和备份的服务器。与我们目前的设置相比，新系统将通过提高功率和灵敏度以及确定我们目前无法做到的轻原子样品绝对配置的能力来增强和扩展功能。具有整体EDX（能量色散X射线光谱）的可变压力FEG-SEM将提供新的能力，并将实现纳米级固体样品的高分辨率成像和元素分析。该仪器将配备温度控制台，我们还将购买能够自动分析多个样品的软件。此外，它将有多个端口，这将允许与进一步的分析工具（如原子力显微镜（AFM））接口。该仪器可以从高真空到低真空操作，提供了最大的灵活性，允许分析导电和非导电样品。我们还需要购买一个金属涂层装置，以涂覆更大的、不导电的样品，这些样品可能容易带电。对可变压力FEG-SEM的要求反映了英国化学研究领域的变化。虽然化学系传统上没有容纳电子显微镜，但随着材料化学等研究领域的重要性不断增长，显微镜的规格不断提高，建议书的B部分提出了建立“高分辨率分析透射电子显微镜（TEM）”中心的理由，该公司购买了最先进的Titan Krios低温电子TEM，将高分辨率2D成像与电子断层扫描和先进的分析技术（电子能量损失谱（EELS）和电子衍射）相结合。该仪器首次使人们能够以如此高的分辨率观察剂量敏感结构，从而使软物质的原子成像成为现实。在B部分中，我们还要求购买用于TEM的液体池保持器以及与A部分中购买的SEM集成的AFM的新功能。粉末XRD也将为学校带来新的能力。最后，我们要求LC-MS（MS）质谱仪取代我们的主力，用户操作的仪器和600 MHz仪器，配备冷探针，将取代现有的仪器，并带来新的分辨率能力。

In Part A of our Bid, the School of Chemistry, University of Leeds requests funds to purchase a 600 MHz NMR Spectrometer, a Single Crystal XRD Spectrometer and a Variable Pressure SEM.The 600 MHz NMR Spectrometer will replace the main service instrument in the School, which is used by 75% of the academic staff. The new instrument will have low and high (variable) temperature and multinuclear capability (including 11B) and is employed for more complex analyses, including selective excitation experiments, more 'exotic' nuclei detection, dynamics studies, and for (very) sample limited data collections. It will also provide increased resolution as compared with the existing instrument and a shielded (high cryogen hold time) magnet and new probes will provide greatly improved signal-to-noise characteristics for all nuclei. The spectrometer will primarily be used to provide the School service, but its superior performance as compared with our old instrument means that the facility can also be opened up to less experienced users for specialist applications. The new single crystal diffractometer system will replace a failing 10 year old instrument and will support the work of approximately 50% of the academic staff in the department, providing vital access to structural determination. The instrument will have a microfocus X-ray source that has dual wavelength (Mo and Cu) capacity, along with peripheral equipment such as a cryogenic crystal cooling unit and server for raw data storage and backup. The new system will have enhanced and expanded capabilities in comparison with our current set-up through improved power and sensitivity, and the ability to determine absolute configuration of light-atom samples which we cannot currently do. A variable pressure FEG-SEM with integral EDX (energy-dispersive X-ray spectroscopy) will provide new capability and will enable high resolution imaging and elemental analysis of solid samples at the nanometer level. The instrument will be equipped with a temperature-control stage, and we will also purchase software enabling automated analysis of multiple samples. In addition, it will have multiple ports which will permit interfacing with further analytical tools (such as atomic force microscopy (AFM)). That the instrument can be operated from high to low vacuum provides maximum flexibility, allowing analysis of both conducting and non-conducting samples. We also need to purchase a metal coating unit to coat larger, non-conducting samples which can be prone to charging. The request of a variable pressure FEG-SEM reflects the changing landscape of chemistry research in the UK. While chemistry departments have not traditionally housed electron microscopes, as research areas such as materials chemistry continue to grow in importance, and the specification of microscopes continues to improve, it is essential that researchers have ready access to high specification instruments.Part B of the proposal makes the case for establishment of a centre for "High Resolution Analytical Transmission Electron Microscopy (TEM) of Beam Sensitive Materials" with purchase of a state-of-the-art Titan Krios cryo-electron TEM which combines high resolution 2D imaging with electron tomography and advanced analytical techniques (electron energy loss spectroscopy (EELS) and electron diffraction). This instrument makes it possible for the first time to look at dose-sensitive structures with such high resolution that atomic imaging of soft matter becomes a reality. In Part B we also request new capability with the purchase of a liquid cell holder for a TEM, and an AFM to integrate with the SEM purchased in Part A. A powder XRD will also bring new capability to the school. Finally, we request a LC-MS(MS) mass spectrometer to replace our workhorse, user-operated instrument and a 600 MHz instrument, equipped with a cold probe which will replace an existing instrument and bring new resolution capabilities.