Chronic Myeloid Leukaemia: Changing the treatment paradigm
慢性粒细胞白血病:改变治疗模式
基本信息
- 批准号:nhmrc : 1138935
- 负责人:
- 金额:$ 78.62万
- 依托单位:
- 依托单位国家:澳大利亚
- 项目类别:Project Grants
- 财政年份:2018
- 资助国家:澳大利亚
- 起止时间:2018-01-01 至 2021-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Most patients with chronic myeloid leukaemia achieve excellent responses to therapy but need therapy for life. We have pioneered the concept that some patients can cease their therapy and not relapse (treatment free remission –TFR). By studying the immune system and the leukaemic stem cells we will determine why TFR is possible for some, but not all patients. This holds the key to improving the rate of TFR, thus moving the CML goal from disease control to cure.
大多数慢性髓性白血病患者对治疗反应良好,但需要终身治疗。我们开创了一些患者可以停止治疗而不会复发的概念(治疗无缓解-TFR)。通过研究免疫系统和白血病干细胞,我们将确定为什么TFR对某些患者是可能的,而不是对所有患者。这是提高TFR率的关键,从而使CML的目标从疾病控制转向治愈。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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A/Pr Susan Branford其他文献
A/Pr Susan Branford的其他文献
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{{ truncateString('A/Pr Susan Branford', 18)}}的其他基金
Defining genomic mechanisms associated with treatment response, drug resistance and early blast crisis in chronic myeloid leukaemia
定义与慢性粒细胞白血病治疗反应、耐药性和早期急变相关的基因组机制
- 批准号:
nhmrc : 1117718 - 财政年份:2017
- 资助金额:
$ 78.62万 - 项目类别:
Research Fellowships
Defining genomic mechanisms associated with treatment response, drug resistance and early blast crisis in chronic myeloid leukaemia
定义与慢性粒细胞白血病治疗反应、耐药性和早期急变相关的基因组机制
- 批准号:
nhmrc : GNT1117718 - 财政年份:2017
- 资助金额:
$ 78.62万 - 项目类别:
Research Fellowships
Determining the prerequisites for the achievement of treatment-free remission in chronic myeloid leukaemia to facilitate the development of new therapeutic approaches with curative intent
确定慢性粒细胞白血病实现免治疗缓解的先决条件,以促进开发具有治愈目的的新治疗方法
- 批准号:
nhmrc : 1059165 - 财政年份:2014
- 资助金额:
$ 78.62万 - 项目类别:
Project Grants
Assessment of markers of genomic instability for the prediction of treatment response in chronic myeloid leukaemia
评估基因组不稳定性标记物以预测慢性粒细胞白血病的治疗反应
- 批准号:
nhmrc : 1027531 - 财政年份:2012
- 资助金额:
$ 78.62万 - 项目类别:
Project Grants
Development and assessment of novel assays to predict response to second-line TKI therapy in imatinib-resistant CML
开发和评估新型检测方法来预测伊马替尼耐药 CML 中二线 TKI 治疗的反应
- 批准号:
nhmrc : 565170 - 财政年份:2009
- 资助金额:
$ 78.62万 - 项目类别:
NHMRC Project Grants
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Chronic Myeloid Leukaemia: Changing the treatment paradigm
慢性粒细胞白血病:改变治疗模式
- 批准号:
nhmrc : GNT1138935 - 财政年份:2018
- 资助金额:
$ 78.62万 - 项目类别:
Project Grants
Optimising Outcomes in Chronic Myeloid Leukaemia Through Rational Drug Selection Using Predictive Assay Results and Maximising Treatment Free Remissions
利用预测分析结果合理选择药物,优化慢性粒细胞白血病的治疗效果,并最大限度地提高无治疗缓解率
- 批准号:
nhmrc : GNT1146253 - 财政年份:2018
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$ 78.62万 - 项目类别:
Early Career Fellowships
Understanding the biological mechanisms involved in treatment free remission of chronic myeloid leukaemia
了解慢性粒细胞白血病无治疗缓解的生物学机制
- 批准号:
nhmrc : 1138079 - 财政年份:2018
- 资助金额:
$ 78.62万 - 项目类别:
Early Career Fellowships
Optimising Outcomes in Chronic Myeloid Leukaemia Through Rational Drug Selection Using Predictive Assay Results and Maximising Treatment Free Remissions
利用预测分析结果合理选择药物,优化慢性粒细胞白血病的治疗效果,并最大限度地提高无治疗缓解率
- 批准号:
nhmrc : 1146253 - 财政年份:2018
- 资助金额:
$ 78.62万 - 项目类别:
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Defining genomic mechanisms associated with treatment response, drug resistance and early blast crisis in chronic myeloid leukaemia
定义与慢性粒细胞白血病治疗反应、耐药性和早期急变相关的基因组机制
- 批准号:
nhmrc : 1117718 - 财政年份:2017
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The role of the bone marrow niche in the maintenance of cancer stem cells in chronic myeloid leukaemia (CML)
骨髓生态位在维持慢性粒细胞白血病(CML)癌症干细胞中的作用
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1938281 - 财政年份:2017
- 资助金额:
$ 78.62万 - 项目类别:
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Defining genomic mechanisms associated with treatment response, drug resistance and early blast crisis in chronic myeloid leukaemia
定义与慢性粒细胞白血病治疗反应、耐药性和早期急变相关的基因组机制
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nhmrc : GNT1117718 - 财政年份:2017
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开发下一代治疗慢性粒细胞白血病的药物
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