Defining genomic mechanisms associated with treatment response, drug resistance and early blast crisis in chronic myeloid leukaemia

定义与慢性粒细胞白血病治疗反应、耐药性和早期急变相关的基因组机制

• 批准号: nhmrc : 1117718
• 负责人: A/Pr Susan Branford
• 金额: $ 43.17万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-genomic-mechanisms-myeloid-leukaemia/946267
• 关键词: Defining; genomic; mechanisms; associated; treatment

Chronic myeloid leukaemia is a fatal disease if untreated. Most patients now survive with new drugs, but some still rapidly die. I aim to understand these differences by investigating the genetic makeup of patients at diagnosis. Some may have gene mutations that prevent drugs from working effectively. Mutations will be detected using technology that can search more than 30,000 genes at the same time. This work could lead to improved survival for more patients by finding new targets for therapy.

慢性粒细胞白血病如果不治疗是一种致命的疾病。大多数病人现在用新药存活下来，但有些人仍然很快死亡。我的目标是通过调查诊断时患者的基因组成来了解这些差异。有些人可能有基因突变，使药物无法有效发挥作用。突变将使用可以同时搜索30，000多个基因的技术进行检测。这项工作可以通过寻找新的治疗靶点来改善更多患者的生存率。