Assessment of markers of genomic instability for the prediction of treatment response in chronic myeloid leukaemia

评估基因组不稳定性标记物以预测慢性粒细胞白血病的治疗反应

• 批准号: nhmrc : 1027531
• 负责人: A/Pr Susan Branford
• 金额: $ 39.35万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/assessment-markers-genomic-myeloid-leukaemia/110576
• 关键词: Assessment; markers; genomic; instability; prediction

The success of therapy for patients with chronic myeloid leukaemia depends on close monitoring during therapy for early recognition of pending relapse, and the selection of appropriate treatment if drug resistance occurs. This project aims to identify patients at the start of therapy who are at risk of treatment failure by investigating their genetic profile. An increased frequency of gene mutations may indicate that patients require more aggressive therapy to achieve an optimal response.

慢性髓性白血病患者治疗的成功取决于治疗期间的密切监测，以早期识别即将复发，并在发生耐药性时选择适当的治疗方法。该项目旨在通过调查患者的基因特征来确定在治疗开始时有治疗失败风险的患者。基因突变频率的增加可能表明患者需要更积极的治疗来达到最佳反应。