Circadian control of peripheral gastric satiety signals

外周胃饱足感信号的昼夜节律控制

• 批准号: nhmrc : 1046289
• 负责人: Prof Amanda Page
• 金额: $ 46.74万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/circadian-control-peripheral-satiety-signals/111834
• 关键词: Circadian; control; peripheral; gastric; satiety

When we feel full after a meal it is the result of a variety of different nerve signals from the gut in response to distension of the stomach and specific nutrients. These signals exhibit circadian variations. The aim of this project is to determine circadian control of gastric nerve satiety signals and to determine how this is affected by obesity and what happens when you disrupt circadian rhythm. This will ultimately identify targets and treatment regimes for the pharmacological treatment of obesity.

当我们在饭后感到饱腹时，这是肠道对胃膨胀和特定营养物质作出反应的各种不同神经信号的结果。这些信号表现出昼夜变化。这个项目的目的是确定胃神经饱腹感信号的昼夜节律控制，并确定肥胖是如何影响这一控制的，以及当你破坏昼夜节律时会发生什么。这将最终确定肥胖药物治疗的靶点和治疗方案。