Plasticity of gastrointestinal vagal afferents

胃肠迷走神经传入的可塑性

• 批准号: DP140102203
• 负责人: Prof Amanda Page
• 金额: $ 38.48万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP140102203
• 关键词: Plasticity; gastrointestinal; vagal; afferents

The aim of this project is to identify how leptin modulates specific subtypes of vagal afferent within the gut and the plasticity of this system under different dietary conditions. This proposed project will substantially increase understanding of the interactions between leptin, known to influence food intake, and vagal afferent satiety signals. It will also increase understanding of how these interactions alter in obesity and ultimately provide targets and/or concepts for the pharmacotherapy of obesity.

该项目的目的是确定瘦素如何调节肠道内迷走神经传入的特定亚型以及该系统在不同饮食条件下的可塑性。该项目将大大增加对瘦素（已知会影响食物摄入）和迷走神经传入饱腹感信号之间相互作用的理解。它还将增进对这些相互作用在肥胖中如何变化的理解，并最终为肥胖的药物治疗提供目标和/或概念。