TRANSNEURONAL SIGNALS FOR AFFERENT REGULATION
用于传入调节的跨神经元信号
基本信息
- 批准号:3461737
- 负责人:
- 金额:$ 10.03万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1992
- 资助国家:美国
- 起止时间:1992-09-01 至 1995-06-30
- 项目状态:已结题
- 来源:
- 关键词:acoustic nerve afferent nerve aminoacid auditory nuclei auditory pathways autoradiography brain stem cell age chickens electrophysiology electrostimulus glutamate receptor immunocytochemistry inositol phosphates microtubule associated protein neural information processing neural transmission neuroanatomy neurons neuropharmacology phospholipase A2 protein biosynthesis protein kinase C second messengers synapses tritium tubulin
项目摘要
Afferent activity has been shown to regulate a number of properties of
postsynaptic neurons. It is well known that afferent input regulates the
electrical activity of postsynaptic neurons through the action of
neurotransmitters. Afferent input, however, also regulates the metabolic
activity of postsynaptic neurons, particularly early in development. The
signals for this latter form of transneuronal regulation are not known.
The brain stem auditory system of the chick has proven to be a useful
system for investigation transneuronal regulation of cellular metabolism.
Second-order auditory neurons in nucleus magnocellularis (NM, the cochlear
nucleus) receive their sole excitatory input from the ipsilateral auditory
nerve. Elimination of activity in the auditory nerve on one side of the
brain has been shown to alter a number of properties of NM neurons. For
example, after a couple of days, a portion of the neurons in NM die and the
rest shrink in size. Early after the elimination of auditory nerve
activity in young chicks, changes in metabolism in NM neurons have been
observed. For example, within 1 hour, there is a dramatic decrease in
protein synthesis by NM neurons on the ipsilateral side of the brain. Such
changes in NM neurons structure and function, however, are not observed
after elimination of auditory nerve activity in adult birds.
The proposed experiments investigate the signals involved in the regulation
of both the electrical activity and metabolic activity of NM neurons.
These experiments will be carried out on both young (1-2 week old) and
adult (1 year old) chickens. Regulation of electrical activity is
investigated first by analyzing the anatomical distribution of different
classes of excitatory amino acid receptors. The physiological effects of
excitatory amino acids are then assessed by application of specific
agonists and antagonists while recording intracellularly from NM neurons in
an in vitro brain slice preparation. Metabolic regulation is investigated
by assessing changes in protein synthesis in the in vitro slice preparation
after various treatments. Unilateral stimulation of the auditory nerve in
vitro has been shown to produce similar changes in protein synthesis as
those observed in vivo. Application of specific agonists and antagonists
will assess the relative roles of different types of excitatory amino acid
receptors and second messenger systems in transneuronal regulation of brain
stem auditory system, 2) an understanding of the signals responsible for
the regulation of neuronal metabolism in this system and 3) an
understanding of age-related differences which may account for the age-
dependence in the sensitivity of neurons to alterations of afferent
activity.
传入活动已经被证明调节了许多特性
突触后神经元。众所周知,传入输入调节着
突触后神经元的电活动
神经递质。然而,传入输入也调节新陈代谢。
突触后神经元的活动,特别是在发育早期。这个
后一种形式的跨神经元调节的信号尚不清楚。
小鸡的脑干听觉系统已被证明是有用的
细胞代谢的跨神经元调节研究系统。
大细胞核(NM)内的二级听神经元
核团)接受来自同侧听觉的唯一兴奋性输入
很有胆量。消除一侧听神经的活动
大脑已被证明可以改变NM神经元的许多特性。为
例如,几天后,NM的部分神经元死亡,
其余的都缩小了。早期消除听神经后
雏鸡的活动,NM神经元代谢的变化
观察到的。例如,在1小时内,
大脑同侧NM神经元的蛋白质合成。是这样的
然而,未观察到NM神经元结构和功能的变化
在成年鸟的听神经活动消除后。
拟议的实验研究了参与调控的信号。
NM神经元的电活动和代谢活动。
这些实验将在幼儿(1-2周大)和
成年(1岁)鸡。对电活动的监管是
首先通过分析不同物种的解剖分布进行调查
兴奋性氨基酸受体的分类。的生理效应
兴奋性氨基酸然后通过应用特定的
NM神经元细胞内记录的激动剂和拮抗剂
一种体外脑片制剂。新陈代谢调节研究
通过评估体外切片制备过程中蛋白质合成的变化
经过各种治疗后。单侧听神经刺激术
体外培养产生的蛋白质合成变化与
那些在体内观察到的。特异性激动剂和拮抗剂的应用
将评估不同类型的兴奋性氨基酸的相对作用
脑跨神经元调节中的受体和第二信使系统
主干听觉系统,2)对负责
该系统中神经元代谢的调节及3)An
理解与年龄有关的差异,这可能解释年龄-
神经元对传入神经变化敏感性的依赖性
活动。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
RICHARD L. HYSON其他文献
RICHARD L. HYSON的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('RICHARD L. HYSON', 18)}}的其他基金
相似海外基金
Data-driven Modeling and Ultrasound-based Control of Afferent Nerve Stimulation for Tremor Suppression
用于抑制震颤的传入神经刺激的数据驱动建模和基于超声的控制
- 批准号:
10453618 - 财政年份:2021
- 资助金额:
$ 10.03万 - 项目类别:
Data-driven Modeling and Ultrasound-based Control of Afferent Nerve Stimulation for Tremor Suppression
用于抑制震颤的传入神经刺激的数据驱动建模和基于超声的控制
- 批准号:
10288130 - 财政年份:2021
- 资助金额:
$ 10.03万 - 项目类别:
Data-driven Modeling and Ultrasound-based Control of Afferent Nerve Stimulation for Tremor Suppression
用于抑制震颤的传入神经刺激的数据驱动建模和基于超声的控制
- 批准号:
10633292 - 财政年份:2021
- 资助金额:
$ 10.03万 - 项目类别:
Establishing appetitive vagal afferent nerve for ameliorating anorexia, frailty, cancer and depression
建立食欲迷走传入神经以改善厌食症、虚弱、癌症和抑郁症
- 批准号:
19K22611 - 财政年份:2019
- 资助金额:
$ 10.03万 - 项目类别:
Grant-in-Aid for Challenging Research (Exploratory)
Screening and profiling of GPCRs in vagal afferent nerve
迷走传入神经 GPCR 的筛选和分析
- 批准号:
18K14845 - 财政年份:2018
- 资助金额:
$ 10.03万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
The mechanism of novel LPA3-mediated activation of vagal afferent nerve
LPA3介导的迷走传入神经激活的新机制
- 批准号:
16K18870 - 财政年份:2016
- 资助金额:
$ 10.03万 - 项目类别:
Grant-in-Aid for Young Scientists (B)
Does renal afferent nerve activation contribute to cardiac sympathoexcitation and decreased renal function in heart failure?
肾传入神经激活是否会导致心脏交感神经兴奋和心力衰竭时肾功能下降?
- 批准号:
nhmrc : 1054619 - 财政年份:2013
- 资助金额:
$ 10.03万 - 项目类别:
Early Career Fellowships
AFFERENT NERVE ACTIV IN ISOL TRACHEA OF INF MONKEYS EXP TO OZONE & ALLERGEN
INF猴隔离气管暴露于臭氧的传入神经活动
- 批准号:
8357239 - 财政年份:2011
- 资助金额:
$ 10.03万 - 项目类别:
AFFERENT NERVE ACTIV IN ISOL TRACHEA OF INF MONKEYS EXP TO OZONE & ALLERGEN
INF猴隔离气管暴露于臭氧的传入神经活动
- 批准号:
8172506 - 财政年份:2010
- 资助金额:
$ 10.03万 - 项目类别:
AFFERENT NERVE ACTIV IN ISOL TRACHEA OF INF MONKEYS EXP TO OZONE & ALLERGEN
INF猴隔离气管暴露于臭氧的传入神经活动
- 批准号:
7958981 - 财政年份:2009
- 资助金额:
$ 10.03万 - 项目类别: