ADVANCED FLOW TECHNOLOGY FOR HEALTHCARE MATERIALS MANUFACTURING

用于医疗保健材料制造的先进流程技术

• 批准号: EP/M015157/1
• 负责人: Asterios Gavriilidis
• 金额: $ 316.29万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM015157%2F1
• 关键词: ADVANCED; FLOW; TECHNOLOGY; HEALTHCARE; MATERIALS

Inorganic nanoparticles have the potential to dramatically modify existing materials while providing the capability to engineer a broad range of transformative new products. Exhibiting unique properties not encountered in bulk materials, inorganic nanoparticles present the opportunity to address, and the potential to overcome, some of the most pressing global challenges. This is leading to intense global competition to develop and commercialize nanoproducts with a variety of applications in healthcare, energy, transport and security, with the aim of acquiring a dominant market position in the nanotechnology sector. Nanoparticles offer ideal solutions for detecting and treating many diseases. They can be used as drug carriers, labelling and tracking agents, and vectors for gene therapy, hyperthermia treatment and magnetic resonance imaging contrast agents. Used as targeted drug-delivery systems, they can improve the performance of medicines already on the market. They enable the development of new therapeutic strategies such as anti-cancer drug delivery, extending product life cycles and reducing healthcare costs. In this proposal we focus on the manufacturing of gold nanoparticles (Au-NPs) and iron oxide magnetic nanoparticles (MNPs). These materials have existing applications in diagnostics and therapeutics. Bespoke monodispersed functionalised NPs offer new applications in antimicrobial surfaces (Au NPs plus dye) and in a new hyperthermia treatment for cancer (MNPs). UCL is at the forefront of the engineering approach to make nanoparticles as well as being world leading in magnetic hyperthermia and antimicrobial surfaces.Nanoparticles are conventionally synthesized in relatively small batch reactors. These systems are poorly controllable, leading to products that are hard to reproduce. Also, they do not lend themselves to expedient upscaling. Such problems are caused by the inefficient mixing and slow heat and mass transfer characterizing batch reactors, and by the difficulty of decoupling in time the various stages of the synthesis, particularly particle nucleation and growth. This research aims to design and demonstrate a new, sustainable and scalable approach for manufacturing high-value nanomaterials with advanced properties in a way that is controllable and reproducible and that does not involve significant upscaling issues. To attain this ambitious goal, we will integrate methods, skills and strengths of different disciplines (materials chemistry, engineering), seeking guidance from industrial partners and UK manufacturing centres. Giving us access to their state-of-the-art facilities, sharing their expertise and providing an application context for our work, they will further characterize the nanoparticles, evaluate their performance and facilitate pathways to manufacture and routes to market.There is currently a lot of research in developing novel materials, where the focus is on discovery but with little emphasis on manufacturing. Using chemical engineering principles and systems engineering methodologies within a multidisciplinary framework, our research will demonstrate not only the need to consider key physical phenomena (mixing, heat transfer etc.) in nanoparticles synthesis, but also how to account and address related manufacturing challenges from the outset. In this way, an important benefit of this project will be to provide a paradigm shift in nanoparticle synthesis and production and bridge the discovery-manufacturing divide.

无机纳米颗粒具有极大地改变现有材料的潜力，同时提供了设计广泛的变革性新产品的能力。无机纳米颗粒表现出块状材料所没有的独特性能，为解决和克服一些最紧迫的全球挑战提供了机会。这导致了激烈的全球竞争，以开发和商业化在医疗保健、能源、运输和安全方面具有各种应用的纳米产品，目的是在纳米技术部门获得主导市场地位。纳米粒子为检测和治疗许多疾病提供了理想的解决方案。它们可以用作药物载体、标记和跟踪剂，以及基因治疗、热疗治疗和磁共振成像造影剂的载体。作为靶向给药系统，它们可以改善市场上已有药物的性能。它们有助于开发新的治疗策略，如抗癌药物输送、延长产品生命周期和降低医疗成本。在本提案中，我们专注于金纳米粒子（Au-NPs）和氧化铁磁性纳米粒子（MNPs）的制造。这些材料在诊断和治疗方面已有应用。定制的单分散功能化NPs在抗菌表面（Au NPs加染料）和新的癌症热疗（MNPs）方面提供了新的应用。伦敦大学学院在制造纳米颗粒的工程方法以及磁热疗和抗菌表面方面处于世界领先地位。纳米颗粒通常是在相对小批量的反应器中合成的。这些系统的可控性很差，导致产品难以复制。此外，它们也不适合权宜之计的升级。这些问题是由于间歇式反应器的混合效率低下和传热传质缓慢，以及合成的各个阶段，特别是颗粒成核和生长难以及时解耦造成的。这项研究旨在设计和展示一种新的、可持续的、可扩展的方法，以一种可控的、可复制的、不涉及重大升级问题的方式，制造具有先进性能的高价值纳米材料。为了实现这一雄心勃勃的目标，我们将整合不同学科（材料化学、工程）的方法、技能和优势，并寻求工业合作伙伴和英国制造中心的指导。让我们使用他们最先进的设施，分享他们的专业知识，并为我们的工作提供应用环境，他们将进一步表征纳米颗粒，评估其性能，并促进制造途径和市场途径。目前在开发新材料方面有很多研究，重点是发现，但很少强调制造。在多学科框架内使用化学工程原理和系统工程方法，我们的研究将证明不仅需要考虑纳米颗粒合成中的关键物理现象（混合，传热等），还需要从一开始就考虑和解决相关的制造挑战。通过这种方式，这个项目的一个重要好处将是提供纳米粒子合成和生产的范式转变，并弥合发现和制造之间的鸿沟。

项目成果

A model for the formation of gold nanoparticles in the citrate synthesis method

• DOI: 10.1016/j.ces.2018.06.046
• 发表时间: 2018-12-14
• 期刊: CHEMICAL ENGINEERING SCIENCE
• 影响因子: 4.7
• 作者: Agunloye, Emmanuel;Panariello, Luca;Mazzei, Luca
• 通讯作者: Mazzei, Luca

Room Temperature Synthesis of Phosphine-Capped Lead Bromide Perovskite Nanocrystals without Coordinating Solvents

• DOI: 10.1002/ppsc.201900391
• 发表时间: 2019-11-19
• 期刊: PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION
• 影响因子: 2.7
• 作者: Ambroz, Filip;Xu, Weidong;Macdonald, Thomas J.
• 通讯作者: Macdonald, Thomas J.

Shape controlled iron oxide nanoparticles: inducing branching and controlling particle crystallinity

• DOI: 10.1039/d0ce01291b
• 发表时间: 2021-01-21
• 期刊: CRYSTENGCOMM
• 影响因子: 3.1
• 作者: AbuTalib, Nur Hanisah;LaGrow, Alec P.;Nguyen Thi Kim Thanh
• 通讯作者: Nguyen Thi Kim Thanh

Structural, optical, electrical, dielectric, molecular vibrational and magnetic properties of La3+ doped Mg-Cd-Cu ferrites prepared by Co-precipitation technique

• DOI: 10.1016/j.ceramint.2022.01.313
• 发表时间: 2022-04-06
• 期刊: CERAMICS INTERNATIONAL
• 影响因子: 5.2
• 作者: Arshad, Muhammad Imran;Hasan, M. S.;Nguyen Thi Kim Thanh
• 通讯作者: Nguyen Thi Kim Thanh