Challenging Ozonolysis

具有挑战性的臭氧分解

• 批准号: EP/G027447/1
• 负责人: Asterios Gavriilidis
• 金额: $ 59.88万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FG027447%2F1
• 关键词: Challenging; Ozonolysis

This proposal is aimed at delivering breakthrough technology for exploiting a number of potentially very valuable reactions that are rarely used in the pharmaceutical industry due to constraints posed by conventional laboratory hardware. The focus is on ozonolysis reactions which are characterised by minimal environmental impact and high efficiency. In spite of these attributes they have not found widespread applications due to safety concerns. Micro channel continuous flow reactors offer an excellent solution to these issues. This is due mainly to the small distances present for mass / heat transfer and quenching, and improved heat management. Ozonolysis is an example of multiphase reactions with fast kinetics and high exothermicity, which can not be performed currently in commercially available flow chemistry systems. In multiphase reactions, reactants from one phase have to pass through an interface, dissolve and then react in another phase. Transport phenomena play a crucial role in reaction performance. Thus, the behaviour of the reaction (which is the prime domain of the chemist) is inexorably linked with transport phenomena (which are the prime domain of the chemical engineer). For this reason, successful development of flow chemistry systems and protocols for multiphase reactions requires input from both disciplines.In this proposal we endeavour to develop novel, easy to use, intrinsically safe, continuous flow, microchannel reactor systems, via collaboration between two research teams with strong track records in organic synthesis and microreaction technology and two industrial partners with expertise in medicinal chemistry and flow chemistry instrumentation. Based on the chemistry of ozone as a hydride acceptor, we aim to identify and exploit completely new, greener, highly efficient and less laborious synthesis pathways that can be employed to manufacture high value compounds of relevance to the pharmaceutical industry from inexpensive raw materials.

该提案旨在提供突破性技术，以利用由于传统实验室硬件的限制而很少用于制药行业的许多潜在的非常有价值的反应。重点是臭氧分解反应，其特点是最小的环境影响和高效率。尽管有这些属性，但由于安全问题，它们没有得到广泛的应用。微通道连续流动反应器为这些问题提供了极好的解决方案。这主要是由于存在用于质量/热传递和淬火的小距离以及改进的热管理。臭氧分解是具有快速动力学和高流动性的多相反应的一个例子，其目前不能在商业上可获得的流动化学系统中进行。在多相反应中，来自一相的反应物必须通过界面，溶解然后在另一相中反应。传输现象在反应性能中起着至关重要的作用。因此，反应的行为（化学家的主要研究领域）与传递现象（化学工程师的主要研究领域）有着不可分割的联系。因此，成功开发流动化学系统和多相反应方案需要两个学科的投入。在本提案中，我们努力开发新颖的、易于使用的、本质安全的、连续流动的微通道反应器系统，通过两个在有机合成和微反应技术方面具有良好记录的研究团队与两个在药物化学和流动方面具有专业知识的工业合作伙伴之间的合作，化学仪器基于臭氧作为氢化物受体的化学性质，我们的目标是识别和开发全新的，更绿色，高效和更省力的合成途径，可用于从廉价的原材料制造与制药工业相关的高价值化合物。

项目成果

Operating ranges of gas-liquid capillary microseparators: Experiments and theory

气液毛细管微分离器的工作范围：实验和理论

• DOI: 10.1016/j.ces.2014.04.017
• 发表时间: 2014
• 期刊: Chemical Engineering Science
• 影响因子: 4.7
• 作者: Roydhouse M

Ozonolysis of some complex organic substrates in flow

流动中一些复杂有机底物的臭氧分解

• DOI: 10.1039/c3ra00125c
• 发表时间: 2013
• 期刊: RSC Advances
• 影响因子: 3.9
• 作者: Roydhouse M

Ozonolysis in Flow Using Capillary Reactors

使用毛细管反应器进行流动臭氧分解

• DOI: 10.1021/op200036d
• 发表时间: 2011
• 期刊: Organic Process Research & Development
• 影响因子: 3.4
• 作者: Roydhouse M