GASTROINTESTINAL FUNCTION--SEROTONERGIC CONTROL

胃肠功能——血清素控制

• 批准号: 3464216
• 负责人: ROBERT L STEPHENS
• 金额: $ 9.72万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-01 至 1995-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3464216
• 关键词: achlorhydria; antiulcer drug; autonomic nervous system; chronic disease /disorder; drug administration rate /duration; duodenal ulcer; gastric acid; gastrointestinal function; gastrointestinal motility /pressure; high performance liquid chromatography; hormone regulation /control mechanism; hyperplasia; intestinal mucosa; laboratory rat; nervous system carcinoma; neural information processing; neuroanatomy; neuroendocrine system; peptic ulcer; secretion; serotonin receptor; stomach emptying

The gastrointestinal tract is controlled by the integration of autonomic nervous system, hormonal, paracrine and neuroendocrine processes. The gut contains a large population of biologically active substances packaged in secretory granules in described "endocrine-paracrine" cells of the mucosa. In mammals, approximately 90% of the content of serotonin is contained in the gastrointestinal tract, predominantly in secretory granules of these "endocrine-paracrine" cells. Serotonin produces marked effects on gastrointestinal function, including effects on gastric acid secretion, motility, gastric emptying and ulcer formation. However, there is a paucity of information available regarding the role of endogenous serotonin to mediate gut function. These studies combine conventional gastric functional methodologies with neuroanatomical, electrophysiological and HLPC techniques to assess the control mechanism of serotonin release into the gastric lumen and portal blood. The functional sequelae of serotonin release on gastric function and its role to mediate gastric emptying of the meal will be determined. The effects of induced hyperplasia of gastric serotonin-secreting cells on gastrointestinal function will be assessed. These studies may provide insight to clinically observed conditions with symptomatology related to hyperplasia of gastrointestinal serotonin. Such conditions include carcinoid syndrome and endocrine cell proliferation subsequent to chronic achlorhydria produced by chronic antiulcer drug therapy or atrophic gastritis.

胃肠道是由自主神经的整合控制的 神经系统、激素、旁分泌和神经内分泌过程。肠道 含有大量生物活性物质，包装在 在所描述的粘膜的“内分泌-旁分泌”细胞中的分泌颗粒。 在哺乳动物中，大约90%的5-羟色胺含量包含在 胃肠道，主要是这些分泌颗粒 “内分泌-旁分泌”细胞。血清素对 胃肠道功能，包括对胃酸分泌的影响， 运动性、胃排空和溃疡形成。然而， 关于内源性5-羟色胺的作用， 调节肠道功能。 这些研究将联合收割机常规胃功能方法学与 神经解剖学、电生理学和HLPC技术来评估 5-羟色胺释放到胃腔和门静脉的控制机制 血5-羟色胺释放对胃功能的功能性后遗症， 将确定其介导膳食的胃排空的作用。的 诱导胃粘膜上皮细胞增生对胃粘膜上皮细胞增殖的影响 将评估胃肠道功能。这些研究可以提供 对临床观察到的疾病的洞察力， 胃肠道血清素增生。这样的条件包括 类癌综合征与慢性胰腺炎后内分泌细胞增殖 慢性抗溃疡药物治疗或萎缩性 胃炎