DNA TOPOISOMERASES IN HEAT SHOCK GENE EXPRESSION
DNA TOPOISOMERASES IN HEAT SHOCK GENE EXPRESSION
批准号:
3466522
负责人:
THOMAS C ROWE
金额:
$9.22万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-07-01 至 1992-06-30
关键词:
DNA gyrase DNA topoisomerases Drosophilidae binding proteins camptothecin chromatin environmental stressor enzyme inhibitors eukaryote gene expression genes genetic manipulation genetic mapping genetic recombination genetic transcription heat nucleic acid sequence regulatory gene stress proteins tissue /cell culture
中文摘要
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英文摘要
Several drugs have recently been identified as specific inhibitors
of eukaryotic DNA topoisomerases. We have shown that these
inhibitors affect the regulation of eukaryotic heat shock gene
expression suggesting a role for these enzymes in this highly
conserved eukaryotic cell function. The emphasis of this proposal
is to use these inhibitors to delineate the function of DNA
topoisomerases in regulating eukaryotic gene expression. The
Drosophila heat-shock system will be used as a model for these
studies.
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REGULATION OF TOPOISOMERASE I AND II PHOSPHORYLATION
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批准号:2100816
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项目类别:
-
资助金额:$13.25万
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财政年份:1993
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负责人:THOMAS C ROWE
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依托单位:
REGULATION OF TOPOISOMERASE I AND II PHOSPHORYLATION
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批准号:2100817
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项目类别:
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资助金额:$13.84万
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财政年份:1993
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负责人:THOMAS C ROWE
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依托单位:
TOPOISOMERASE II-ACTIVE DRUGS IN MITOCHONDRIA
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批准号:2185009
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项目类别:
-
资助金额:$13.7万
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财政年份:1993
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负责人:THOMAS C ROWE
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依托单位:
REGULATION OF TOPOISOMERASE I AND II PHOSPHORYLATION
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批准号:3203911
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项目类别:
-
资助金额:$12.66万
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财政年份:1993
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负责人:THOMAS C ROWE
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依托单位:
TOPOISOMERASE II-ACTIVE DRUGS IN MITOCHONDRIA
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批准号:2185008
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项目类别:
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资助金额:$13.26万
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财政年份:1993
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负责人:THOMAS C ROWE
-
依托单位:
EFFECTS OF TOPOISOMERASE II-ACTIVE DRUGS IN MITOCHONDRIA
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批准号:3307060
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项目类别:
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资助金额:$12.59万
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财政年份:1993
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负责人:THOMAS C ROWE
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依托单位:
REGULATION OF TOPOISOMERASE I AND II PHOSPHORYLATION
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批准号:2100815
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项目类别:
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资助金额:$12.57万
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财政年份:1993
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负责人:THOMAS C ROWE
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依托单位:
TOPOISOMERASE II-ACTIVE DRUGS IN MITOCHONDRIA
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批准号:2185010
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项目类别:
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资助金额:$14.29万
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财政年份:1993
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负责人:THOMAS C ROWE
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依托单位:
DNA TOPOISOMERASES IN HEAT SHOCK GENE EXPRESSION
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批准号:3466523
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项目类别:
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资助金额:$9.03万
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财政年份:1987
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负责人:THOMAS C ROWE
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依托单位:
DNA TOPOISOMERASES IN HEAT SHOCK GENE EXPRESSION
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批准号:3466521
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项目类别:
-
资助金额:$9.52万
-
财政年份:1987
-
负责人:THOMAS C ROWE
-
依托单位:
DNA TOPOISOMERASES IN HEAT SHOCK GENE EXPRESSION
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批准号:3466524
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项目类别:
-
资助金额:$10.52万
-
财政年份:1987
-
负责人:THOMAS C ROWE
-
依托单位:
DNA TOPOISOMERASES IN HEAT SHOCK GENE EXPRESSION
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批准号:3466525
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项目类别:
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资助金额:$10.79万
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财政年份:1987
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负责人:THOMAS C ROWE
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依托单位:
海外基金