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DNA TOPOISOMERASES IN HEAT SHOCK GENE EXPRESSION

DNA TOPOISOMERASES IN HEAT SHOCK GENE EXPRESSION
热休克基因表达中的 DNA 拓扑异构酶
批准号:
3466523
负责人:
THOMAS C ROWE
金额:
$9.03万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
1987
资助国家:
美国
项目状态:
已结题
起止时间:
1987-07-01 至 1992-06-30

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中文摘要
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英文摘要
Several drugs have recently been identified as specific inhibitors of eukaryotic DNA topoisomerases. We have shown that these inhibitors affect the regulation of eukaryotic heat shock gene expression suggesting a role for these enzymes in this highly conserved eukaryotic cell function. The emphasis of this proposal is to use these inhibitors to delineate the function of DNA topoisomerases in regulating eukaryotic gene expression. The Drosophila heat-shock system will be used as a model for these studies.
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REGULATION OF TOPOISOMERASE I AND II PHOSPHORYLATION
  • 批准号:
    2100816
  • 项目类别:
  • 资助金额:
    $13.25万
  • 财政年份:
    1993
  • 负责人:
    THOMAS C ROWE
  • 依托单位:
REGULATION OF TOPOISOMERASE I AND II PHOSPHORYLATION
  • 批准号:
    2100817
  • 项目类别:
  • 资助金额:
    $13.84万
  • 财政年份:
    1993
  • 负责人:
    THOMAS C ROWE
  • 依托单位:
TOPOISOMERASE II-ACTIVE DRUGS IN MITOCHONDRIA
  • 批准号:
    2185009
  • 项目类别:
  • 资助金额:
    $13.7万
  • 财政年份:
    1993
  • 负责人:
    THOMAS C ROWE
  • 依托单位:
REGULATION OF TOPOISOMERASE I AND II PHOSPHORYLATION
  • 批准号:
    3203911
  • 项目类别:
  • 资助金额:
    $12.66万
  • 财政年份:
    1993
  • 负责人:
    THOMAS C ROWE
  • 依托单位:
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