ATTENTION DEFICITS IN MENTALLY RETARDED CHILDREN

弱智儿童的注意力缺陷

• 批准号: 3475714
• 负责人: DEBORAH Ann PEARSON
• 金额: $ 11.38万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-09-30 至 1997-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3475714
• 关键词: age difference; attention; attention deficit disorder; dosage; human subject; human therapy evaluation; mental disorder chemotherapy; mental retardation; methylphenidate; middle childhood (6-11); stimulant /agonist

The nature and severity of the attention deficits and behavior problems associated with Attention Deficit Hyperactivity Disorder (ADHD) in children ages 8-16 with Mental Retardation (MR) will be explored. This proposed project will be a continuation of an NIMH Small Grant and will use the attentional measures developed in that Small Grant to compare MR children with ADHD ("MR/ADHD") to MR children without ADHD ("MR/non-ADHD") in order to ascertain which components of attention (sustained attention, impulsivity, selective attention, immediate memory) are problematic in MR/ADHD children. This difference between MR/ADHD children and MR/non-ADHD will be compared to the difference between mental age matched ADHD and non-ADHD children of normal intelligence to explore the relationship between ADHD and MR with regard to attention. Since it is hypothesized that MR and ADHD are not entirely unrelated to each other, the pattern of attention deficits associated with ADHD in MR children is predicted to be different from the pattern of attentional deficits noted in ADHD children of normal intelligence. Finally, stimulant treatment of ADHD will be assessed using placebo, 0.15 mg/kg, 0.3 mg/kg, and 0.6 mg/kg of methylphenidate in a double-blind, placebo-controlled, crossover design with the MR/ADHD children and the mental age matched ADHD children to determine optimal dosages of this medication in regard to attentional processes and behavior for both of these two groups.

注意力缺陷和行为问题的性质和严重性 与注意力不足多动症（ADHD）相关 将探讨8-16岁的儿童智力低下（MR）。 这 拟议的项目将是NIMH小的延续 赠款并将使用该小赠款中制定的注意力措施 将儿童先生与ADHD（“ MR/ADHD”）与没有多动症的儿童进行比较 （“ MR/NON-ADHD”）为了确定关注的组成部分 （持续关注，冲动，选择性关注，立即记忆） 在MR/ADHD儿童中有问题。 MR/ADHD之间的差异 将将儿童和MR/非ADHD与 精神年龄与正常智力的ADHD和非ADHD儿童相匹配 在注意力方面探索多动症与MR之间的关系。 由于假设MR和ADHD与 彼此，MR中与ADHD相关的注意力缺陷模式 预计儿童与注意力的模式不同 正常智力的多动症儿童中指出的赤字。 最后， ADHD的刺激治疗将使用安慰剂，0.15 mg/kg评估 0.3 mg/kg和双盲中的0.6 mg/kg哌醋甲酯， 安慰剂控制的，MR/ADHD儿童的跨界设计和 精神年龄与多动症儿童相匹配，以确定这一点的最佳剂量 关于注意力过程和行为的药物 这两组。