ADHD Symptoms in Autism: Cognition, Behavior, Treatment

自闭症的多动症症状：认知、行为、治疗

• 批准号: 6929581
• 负责人: DEBORAH Ann PEARSON
• 金额: $ 29.49万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-12 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6929581
• 关键词: attention; attention deficit disorder; autism; behavioral /social science research tag; child psychology; clinical research; clinical trials; comorbidity; human subject; human therapy evaluation; impulsive behavior; mental disorder chemotherapy; methylphenidate; middle childhood (6-11); patient oriented research; psychological tests; psychopharmacology; questionnaires

DESCRIPTION (provided by applicant): The proposed project, submitted in response to PA-04-085 will study cognitive and behavioral functioning in children with DSM-IV Autistic Disorder who also manifest symptoms of Attention Deficit Hyperactivitv Disorder (ADHD). Although the DSM-IV does not specifically allow for a comorbid diagnosis of ADHD with Autism, many children with Autism manifest symptoms of ADHD, and many are treated for it. There have been few studies on ADHD in Autism, so little is known about its cognitive and behavioral manifestations, or the optimal parameters for treatment. The proposed project will address these issues by examining cognitive and behavioral functioning in children with Autism who manifest symptoms of ADHD, as well as their response to stimulant medication treatment. Building upon techniques developed in the PI's previous NIMH-funded studies (MH044118 and MH48212, DA Pearson, PI) as well as her collaborative work in a current NICHD autism program project (HD035471; KA Loveland, PI; DA Pearson, Co-lnv.), this proposed study will address two Specific Aims. In Specific Aim 1, cognitive and behavioral functioning as well as comorbid psychiatric symptomatology will be compared in: 1) children with Autism who manifest symptoms of ADHD ("Autism/ADHD"), and 2) children with Autism who do not manifest symptoms of ADHD ("Autism/non-ADHD"). In both groups, children will be 7-12 years old, with an IQ of 50-130. It is hypothesized that relative to children, children in the Autism/non-ADHD group, with Autism/ADHD will have greater deficits in attention and inhibition, as well as more internalizing and externalizing psychiatric symptomatology. In Specific Aim 2, the cognitive and behavioral response to placebo, low, medium, and high doses of methylphenidate (MPH) in children with Autism/ADHD will be studied in a medication treatment trial, using a double-blind, placebo-controlled, crossover design to determine optimal MPH dosages. It is hypothesized that higher MPH doses will produce successive improvements in cognitive and behavioral functioning in children with Autism/ADHD. Thus, the primary goals of the proposed research are to characterize ADHD in school-aged children with Autistic Disorder (DSM-IV), and to assess their cognitive and behavioral response to MPH.

描述（由申请人提供）：响应于PA-04-085提交的拟议项目将研究DSM-IV自闭症儿童的认知和行为功能，他们也表现出注意力缺陷症状超伴侣障碍（ADHD）的症状。尽管DSM-IV并未明确允许对ADHD进行自闭症的合并诊断，但许多自闭症儿童表现出ADHD的症状，许多儿童都对此进行了治疗。关于自闭症的多动症的研究很少，因此对其认知和行为表现或治疗的最佳参数知之甚少。拟议的项目将通过检查表现出ADHD症状的自闭症儿童的认知和行为功能以及对刺激药物治疗的反应来解决这些问题。 基于PI先前的NIMH资助研究（MH044118和MH48212，DA PEARSON，PI）的技术，以及她在当前NICHD自闭症计划项目（HD035471; KA Loveland，pi; pi; pi; dapearson; daeperson; daeperson; daepens; da pearson; da pearson; daep; da pearson''的合作工作将解决两个特定的研究。在特定目标1中，将在以下方面比较认知和行为功能以及合并症的精神病症状学，以：1）自闭症儿童表现出ADHD的症状（“自闭症/ADHD”），以及2）自闭症儿童没有表现出ADHD症状的儿童（“自闭症/非ADHD”）。在这两组中，儿童将年满7-12岁，智商为50-130。假设相对于儿童，自闭症/非ADHD组的儿童具有自闭症/ADHD的注意力和抑制作用，以及更多的内在化和外在化精神病症状学。在特定的目标2中，使用双盲，安慰剂对照，交叉设计以确定最佳MPH剂量的药物治疗试验，将对自闭症/ADHD儿童的安慰剂，低剂量和高剂量的哌醋甲酯（MPH）的认知和行为反应进行研究。假设较高的MPH剂量将在自闭症/ADHD儿童的认知和行为功能方面连续改善。因此，拟议的研究的主要目标是表征自闭症患者（DSM-IV）的学龄儿童的多动症，并评估其对MPH的认知和行为反应。