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Optimisation of vertebroplasty to minimise adjacent vertebral failure

优化椎体成形术以尽量减少邻近椎体衰竭

基本信息

批准号：
EP/D002710/1
负责人：
Ruth Wilcox
金额：
$ 26.91万
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2006
资助国家：
英国
起止时间：
2006 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FD002710%2F1
关键词：
Optimisation vertebroplasty minimise adjacent vertebral

项目摘要

Many elderly people suffer from osteoporosis, which causes their bones to break very easily. One of the most common places for a fracture to occur is in the vertebrae of the spine. These fractures are difficult to treat and many patients suffer from long-term pain. Recently, a new method of keyhole surgery has been introduced to treat these types of injury. The treatment, called 'vertebroplasty' involves injecting a special cement through a fine needle into the spine to hold the fracture together. Early results have been positive, with the majority of patients saying they are in much less pain after the treatment. However, recently there have been reports that vertebroplasty may increase the risk of the patient having more fractures in the surrounding vertebrae. At the moment, little is know about how stiff the cement should be or how much to inject. The aim of this project is to develop computer models of the spine that can be used to predict what effects the cement will have on the surrounding region of the spine. To check these models make the right predictions, the results first need to be checked against experimental tests undertaken in the laboratory. Then, the computer models will be used to compare many different types and volumes of cement. The aim is to find the optimum combination that will reduce the risk of more fractures happening in the surrounding vertebrae.

许多老年人患有骨质疏松症，这导致他们的骨头很容易断裂。骨折最常见的部位之一是脊柱的椎骨。这些骨折很难治疗，许多患者遭受长期疼痛。最近，一种新的锁孔手术方法被引入来治疗这些类型的损伤。这种被称为“椎体成形术”的治疗方法是通过细针将一种特殊的骨水泥注入脊柱，以将骨折处固定在一起。早期的结果是积极的，大多数患者说他们在治疗后疼痛减轻了很多。然而，最近有报道称，椎体成形术可能会增加患者周围椎骨发生更多骨折的风险。目前，人们对水泥的硬度和注入量知之甚少。该项目的目的是开发脊柱的计算机模型，用于预测骨水泥对脊柱周围区域的影响。为了检查这些模型是否做出正确的预测，首先需要将结果与实验室进行的实验测试进行比较。然后，计算机模型将用于比较许多不同类型和体积的水泥。目的是找到最佳组合，以降低周围椎骨发生更多骨折的风险。