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Engineering solutions to back pain: an interdisciplinary approach

背痛的工程解决方案：跨学科方法

基本信息

批准号：
EP/F010575/1
负责人：
Ruth Wilcox
金额：
$ 137.99万
依托单位：
University of Leeds
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2008
资助国家：
英国
起止时间：
2008 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FF010575%2F1
关键词：
Engineering solutions back pain interdisciplinary

项目摘要

At some point during our lifetimes, eight out of ten of us will experience low back pain. For some, a course of painkillers and a period of recovery will be enough to alleviate the symptoms, but this is not always the case and many people continue to suffer long term pain and discomfort. In joints such as the hip and knee, replacement surgery has become commonplace and is highly successful in reducing pain and restoring movement. In the spine however, corresponding treatments are still in their infancy and have yet to prove their long term effectiveness.It may seem farfetched to imagine that in less than two decades spinal treatments could develop to a level where back pain will be effectively treated using keyhole surgery and other minimally invasive techniques. However it is not beyond the realms of possibility if progress in the basic sciences along with developments in imaging and computer modelling continue. Perhaps most importantly, the understanding accrued in these many disciplines must be effectively harnessed and integrated. The aim of this research is to enable such a step change in spinal treatments to occur. Through the Exploration Funding, computer models of the spine will be developed in collaboration with experts from the basic sciences as well as clinicians and industrialists. These models will be used to investigate new implant materials and treatment techniques for back pain.The spine constantly undergoes complex biological, biochemical and mechanical processes which must be taken into account if new treatments are to be effective. Experimental tests will be used to assess these factors in isolation and the results combined into the computer models. There is much variation in the properties of the spinal structures both from one patient to another, and even along the length of an individual's back. These variations will also be simulated in the computer models to see how effective a treatment will be for a range of different patients. The computer models will enable new spinal treatments to be developed and optimised to bring maximum benefit to the patient before they are introduced into hospitals.By the end of the five year period of the Exploration Funding, a new and reliable method of testing spinal interventions will have been developed and research initiated to create a range of novel optimised treatments for back pain. In ten years time, this could lead to a new range of treatment options and, by 2020, effective minimally invasive treatment for back pain could become a reality.

在我们一生中的某个时刻，十分之八的人会经历腰痛。对于某些人来说，一个疗程的止痛药和一段时间的恢复就足以缓解症状，但情况并非总是如此，许多人继续遭受长期的疼痛和不适。在髋关节和膝关节等关节中，置换手术已变得司空见惯，并且在减轻疼痛和恢复运动方面非常成功。然而，在脊柱方面，相应的治疗仍处于起步阶段，尚未证明其长期有效性。想象在不到二十年的时间内脊柱治疗可以发展到使用锁孔手术和其他微创技术有效治疗背痛的水平，似乎有些牵强。然而，如果基础科学的进步以及成像和计算机建模的发展继续下去，这并非超出了可能性的范围。也许最重要的是，必须有效地利用和整合在这些许多学科中积累的理解。这项研究的目的是使脊柱治疗发生这样的一步改变。通过探索资金，将与基础科学专家以及临床医生和实业家合作开发脊柱计算机模型。这些模型将用于研究新的植入材料和背痛治疗技术。脊柱不断经历复杂的生物、生化和机械过程，如果新的治疗方法要有效，就必须考虑到这些过程。实验测试将用于单独评估这些因素，并将结果合并到计算机模型中。不同患者的脊柱结构特性存在很大差异，甚至沿着个体背部的长度也存在很大差异。这些变化也将在计算机模型中进行模拟，以了解治疗对一系列不同患者的效果如何。这些计算机模型将能够开发和优化新的脊柱治疗方法，以便在将其引入医院之前为患者带来最大的益处。在探索资助的五年期限结束时，将开发出一种新的可靠的脊柱干预测试方法，并启动研究，以创造一系列针对背痛的新型优化治疗方法。十年后，这可能会带来一系列新的治疗选择，到 2020 年，有效的微创治疗背痛可能成为现实。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Bone ageing and structural disconnection

骨骼老化和结构断裂

DOI：
发表时间：
2012
期刊：
影响因子：
0
作者：
Garner Philippa Elizabeth
通讯作者：
Garner Philippa Elizabeth

Comparison between FEBio and Abaqus for biphasic contact problems.

DOI：
10.1177/0954411913483537
发表时间：
2013-09
期刊：
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
影响因子：
0
作者：
Meng Q;Jin Z;Fisher J;Wilcox R
通讯作者：
Wilcox R

Computational simulation of the intervertebral disc

椎间盘的计算模拟