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REPAIRABILITY OF OXIDATIVE DAMAGE TO DNA

REPAIRABILITY OF OXIDATIVE DAMAGE TO DNA
DNA 氧化损伤的修复能力
批准号：
3481747
负责人：
GEORGE W TEEBOR
金额：
$22.43万
依托单位：
NEW YORK UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1978
资助国家：
美国
项目状态：
已结题
起止时间：
1978-08-01 至 1993-03-31
来源：
https://reporter.nih.gov/project-details/3481747
关键词：
5 methylcytosine 6 thioguanine DNA repair Escherichia coli HeLa cells complementary DNA cyclophosphamide drug design /synthesis /production endodeoxyribonuclease enzyme mechanism gene expression gene mutation glycosyltransferase high performance liquid chromatography infrared spectrometry ionizing radiation laboratory rabbit mass spectrometry mutagens nonvisual photosensitivity ouabain oxidative phosphorylation oxidizing agents radiation genetics radiation sensitivity radiobiology radiotracer scintillation spectrometry thin layer chromatography thymine ultraviolet radiation uracil analog

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英文摘要
Ionizing radiation and other oxidative stresses modify the bases in DNA. Several of these bases are substrates for DNA repair enzymes which is evidence that they are also modified by endogenous oxidants. This proposal continues to study formation of derivatives of thymine and cytosine in DNA exposed to oxidative stress. The potential mutagenicity of these modified bases will be studied. A repair enzyme, 5-hydroxymethyluracil-N- glycosylase will be purified so that its genetic expression may be studied. 32P-post labelling techniques for identification of these bases in vivo will be developed.
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GENOMIC DISTRIBUTION AND PHYLOGENY OF DNA REPAIR
  • 批准号：
    2093493
  • 项目类别：
  • 资助金额：
    $20.68万
  • 财政年份：
    1989
  • 负责人：
    GEORGE W TEEBOR
  • 依托单位：
    NEW YORK UNIVERSITY
GENOMIC DISTRIBUTION AND PHYLOGENY OF DNA REPAIR
  • 批准号：
    3194185
  • 项目类别：
  • 资助金额：
    $11.65万
  • 财政年份：
    1989
  • 负责人：
    GEORGE W TEEBOR
  • 依托单位：
    NEW YORK UNIVERSITY
FORMATION, MUTAGENICITY & REPAIR OF PHOTOHYDRATES IN DNA
GENOMIC DISTRIBUTION AND PHYLOGENY OF DNA REPAIR
  • 批准号：
    3194187
  • 项目类别：
  • 资助金额：
    $21.14万
  • 财政年份：
    1989
  • 负责人：
    GEORGE W TEEBOR
  • 依托单位：
    NEW YORK UNIVERSITY
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