Development and optimisation of downstream processing for next generation biotherapeutics

下一代生物治疗药物下游加工的开发和优化

• 批准号: EP/N013395/1
• 负责人: Daniel Bracewell
• 金额: $ 46.28万
• 依托单位: University College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FN013395%2F1
• 关键词: Development; optimisation; downstream; processing; next

In recent years there has been rapid development of a "Next Generation" of protein-based therapeutics, yet the need remains for new manufacturing processes that can deliver these at a price healthcare providers can afford. For the first time these new therapies can safely modify a patient's DNA, or harness the body's own immune system, to treat inherited diseases, neurological conditions, and cancer. However, to achieve this clinical functionality the complexity and size of the therapeutic protein has increased. This has meant that existing purification technologies have been unable to be applied effectively in this new application. This project aims to build on existing collaborations and feasibility data to develop new purification tools and strategies that can be applied across a range of next generation biotherapeutics to enable their cost effective manufacture delivering novel therapies to patients at an aceeptable price for healthcare payers.

近年来，“下一代”基于蛋白质的治疗药物发展迅速，但仍然需要新的制造工艺，以医疗保健提供者可以负担得起的价格提供这些药物。这些新疗法首次可以安全地修改患者的DNA，或利用人体自身的免疫系统来治疗遗传性疾病、神经系统疾病和癌症。然而，为了实现这种临床功能，治疗蛋白的复杂性和大小都增加了。这意味着现有的净化技术已无法有效地应用于这一新的应用。该项目旨在以现有的合作和可行性数据为基础，开发新的纯化工具和策略，这些工具和策略可以应用于一系列下一代生物疗法，使其生产具有成本效益，并以医疗保健支付者可接受的价格向患者提供新疗法。

项目成果

Cover Image, Volume 116, Number 7, July 2019

封面图片，第 116 卷，第 7 号，2019 年 7 月

• DOI: 10.1002/bit.26760
• 发表时间: 2019
• 期刊: Biotechnology and Bioengineering
• 影响因子: 3.8
• 作者: Turnbull J

Lentiviral Vector Purification Using Nanofiber Ion-Exchange Chromatography.

使用纳米纤维离子交换色谱法纯化慢病毒载体。

• DOI: 10.1016/j.omtm.2019.08.007
• 发表时间: 2019
• 期刊: Molecular therapy. Methods & clinical development
• 作者: Ruscic J

Adenovirus 5 recovery using nanofiber ion-exchange adsorbents.

使用纳米纤维离子交换吸附剂回收腺病毒 5。

• DOI: 10.1002/bit.26972
• 发表时间: 2019
• 期刊: Biotechnology and bioengineering
• 影响因子: 3.8
• 作者: Turnbull J