Digital design and fabrication of advanced biopurification materials

全球对癌症治疗和疫苗等复杂生物药物的需求继续增长。然而，利用现有技术大规模生产高质量产品的能力仍然具有挑战性。对基于病毒载体和脂质体的产品的生产能力和需求的提高导致下游净化问题加剧，导致过滤和层析等生物制造单元操作的性能和寿命受到影响。为了以高效和经济高效的方式净化日益浓缩的工艺流程，以满足日益增长的生物治疗需求，需要解决方案。这里提出的研究利用尖端3D成像、分析和数字设计方法来生产与现有净化技术相比具有明显优势的新型生物分离材料。应用在伦敦大学学院建立的方法论，可以通过3D打印设计、制造、分析和改进设计周期。Pall Biotech是一家领先的国际生物工艺供应商和应用专家，该公司将提供借调机会，使其能够获得这项研究的行业专家和行业相关材料，以便进行商业适用的案例研究。

The global need for complex biological medicines such as cancer treatments and vaccines continues to grow. However the capability to manufacture high quality products at scale remains challenging with existing technology. Improvements to production capabilities and demand for products based on viral vectors and liposomes have resulted in exacerbated purification issues downstream, leading to performance and lifespan compromises of biomanufacturing unit operations such as filtration and chromatography. Solutions are required in order purify ever increasingly concentrated process streams in an efficient and cost-effective manner to meet growing demand for bio-therapeutics.The research proposed here utilises cutting-edge 3D imaging, analysis and digital design approaches in order to produce novel bioseparation materials that have clear advantages over existing purification technology. Applying methodology established at UCL structures can be designed, fabricated through 3D printing, analysed and improved through a design cycle. Pall Biotech, a leading international bioprocess vendor and applications expert, will provide secondment opportunities that will enable access to industrial experts and industrially relevant materials for this research in order to perform commercially applicable case studies.