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Nanofibre scale-up and industrial validation - Industrial Biotechnology Catalyst Translation and Industrial Research Awards

纳米纤维放大和工业验证 - 工业生物技术催化剂转化和工业研究奖

基本信息

批准号：
EP/M017222/1
负责人：
Daniel Bracewell
金额：
$ 77.55万
依托单位：
University College London
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2015
资助国家：
英国
起止时间：
2015 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FM017222%2F1
关键词：
Nanofibre scale up industrial validation

项目摘要

Biopharmaceuticals are an increasingly important sector of the pharmaceutical industry, over one third of all drugs now in development are biopharmaceuticals and they make up half of the top 10 revenue blockbusters. It typically takes over 10 years and $800 million to develop a new drug. Global demand for cheaper biotherapeutics, which represent many of the new tools in the fight against diseases such as cancer and neurodegenerative conditions, drives the need for a reduction in manufacturing costs. A significant proportion of current costs arise from the purification technologies now used to ensure the safety and efficacy of these treatments. This project aims to build on existing collaborations between Puridify, an SME with a novel nanofibre purification technology, and University College London (UCL), a world leading research organisation for the development of industrial bioprocessing technologies. The successful award of this project lead by Puridify and supported by shadow industrial partners will see the development and commercialisation of innovative bioprocessing platform technologies allowing the cost effective manufacture of a wide range of existing and new products.The project will accelerate development of Puridify's novel platform downstream bioprocessing technologies towards commercial activity. The technologies increased productivity will provide an efficient manufacturing route to both new and existing products benefiting society and the sector as a whole by reducing costs and enabling the economic manufacture of next generation biotherapeutics. Using new processing technologies, theory and modelling, this integrated Industrial Research and Development project will accelerate the commercialisation of this technology by bringing together key academic and business components of the UK Industrial Biotechnology community.

生物制药是制药行业越来越重要的一个部门，目前正在开发的所有药物中有三分之一以上是生物制药，它们占前十大收入大片的一半。开发一种新药通常需要10年以上的时间和8亿美元。全球对更便宜的生物治疗药物的需求，代表了对抗癌症和神经退行性疾病等疾病的许多新工具，推动了降低制造成本的需求。目前的成本中有很大一部分来自目前用于确保这些处理的安全性和有效性的净化技术。该项目旨在巩固Puridify（一家拥有新型纳米纤维纯化技术的中小企业）与伦敦（UCL）（一家世界领先的工业生物加工技术开发研究机构）之间的现有合作。该项目由Purify牵头，并得到影子工业合作伙伴的支持，该项目的成功授予将见证创新生物加工平台技术的开发和商业化，从而实现各种现有产品和新产品的成本效益生产。该项目将加速Purify新型平台下游生物加工技术的商业化发展。这些技术提高了生产力，将为新产品和现有产品提供一条高效的制造路线，通过降低成本和实现下一代生物治疗药物的经济制造，造福社会和整个行业。利用新的加工技术，理论和建模，这个综合的工业研究和开发项目将通过汇集英国工业生物技术界的关键学术和商业组成部分来加速这项技术的商业化。