课题基金 / 基金详情

STRUCTURAL KINETIC STUDIES BY NUCLEAR MAGNETIC RESONANCE

STRUCTURAL KINETIC STUDIES BY NUCLEAR MAGNETIC RESONANCE
核磁共振结构动力学研究
批准号：
3484347
负责人：
ALFRED Guillou REDFIELD
金额：
$16.54万
依托单位：
BRANDEIS UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1976
资助国家：
美国
项目状态：
已结题
起止时间：
1976-06-01 至 1991-07-31
来源：
https://reporter.nih.gov/project-details/3484347
关键词：
allosteric site aminoacid tRNA ligase bacteria bacterial RNA chemical reaction conformation enzyme complex enzyme structure microorganism culture molecular site nuclear magnetic resonance spectroscopy nucleic acid structure radiotracer stable isotope transfer RNA

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英文摘要
NMR Spectroscopy will continue to be applied to determine the structure and dynamics of transfer RNA in interaction with the enzyme aminoacyl tRNA synthetase. These two macromolecules are essential parts of the biosynthetic machinery of all living things. The emphasis is on use of isotope labels of 15N and 13C to highlight proton NMR signals and provide more information than straight NMR spectroscopy. Smaller molecules interacting with the enzyme, as well as labelled enzyme and labelled tRNA, will be examined to provide information on molecular changes during function of the molecules. The NMR methods being used are prototypical of methods potentially applicable to drug design.
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Applications of Field-Cycling NMR to Studies of Biomolecules.
  • 批准号：
    6963056
  • 项目类别：
  • 资助金额：
    $15.4万
  • 财政年份：
    2005
  • 负责人：
    ALFRED Guillou REDFIELD
  • 依托单位：
    BRANDEIS UNIVERSITY
Applications of Field-Cycling NMR to Studies of Biomolecules
  • 批准号：
    7283043
  • 项目类别：
  • 资助金额：
    $14.6万
  • 财政年份：
    2005
  • 负责人：
    ALFRED Guillou REDFIELD
  • 依托单位：
    BRANDEIS UNIVERSITY
Applications of Field-Cycling NMR to Studies of Biomolecules.
  • 批准号：
    7124729
  • 项目类别：
  • 资助金额：
    $15.04万
  • 财政年份：
    2005
  • 负责人：
    ALFRED Guillou REDFIELD
  • 依托单位：
    BRANDEIS UNIVERSITY
Applications of Field-Cycling NMR to Studies of Biomolecules
  • 批准号：
    7493388
  • 项目类别：
  • 资助金额：
    $14.6万
  • 财政年份：
    2005
  • 负责人：
    ALFRED Guillou REDFIELD
  • 依托单位：
    BRANDEIS UNIVERSITY