DEVELOPMENT OF A NEW CORNEAL AESTHESIOMETER AND NORMS

新型角膜感觉计和标准的开发

• 批准号: 3496814
• 负责人: SIDNEY WEINSTEIN
• 金额: $ 5万
• 依托单位: NEUROCOMMUNICATION RESEARCH LABS, INC.
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-05-01 至 1987-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3496814
• 关键词: alcoholic beverage consumption; clinical biomedical equipment; conjunctiva; contact lens; cornea; evoked potentials; eyelid disorder; human age group; human subject; sclera; sensorimotor system; sex differentiation; tobacco

Specific Aims: Modify existing Weinstein Oral Microaesthesiometer to create a new instrument to test corneal somatosensation. Determine validity and test-retest reliability of device, and establish norms on a small group of subjects. Separately measure and compare corneal thresholds obtained psychophysically and by means of cortical evoked potentials. Explore, post hoc, in a small group, the effects of: age, sex, contact lenses, and use, e.g., of tobacco, alcohol, etc. Long Term Objectives: Establish commercial potential and age/sex norms. Results Expected During Phase I: Create safe, valid, precise, reliable device for testing corneal, scleral, conjunctival and eyelid somatic sensation. ln a small group, establish limited age and sex norms, and sample effects, e.g., of contact lenses and use of substances such as tobacco, alcohol, etc. Potential for Technological lnnovation and Commercial Application: Thr existing instrument, which will be the prototype for this device, The Weinstein Oral Microaesthesiometer, is a valid, precise, and reliable instrument for testing oral cavity sensation. The potential exists for its conversion into a corneal microaesthesiometer, which would have numerous advantages over existing instruments. For example, it alone could be used in the measurement of cortical evoked potentials in nonverbal humans (infants, retardates, etc.) and in animals. The following disadvantages of current devices are not possible with this device: 1. risk of infection, as with hairs or threads, 2. injuring the cornea, as with platinum wires, 3. inability to go below the threshold force, 4. inducing apprehension with visible stimuli. Commercial application which may result from this study: creation of a device for sale to ophthalmologists, optometrists, clinics, laboratories, and schools of medicine and optometry.

具体目的：修改现有的Weinstein口腔微感觉计 创造一种新的仪器来测试角膜体感。 确定器械的有效性和重测信度，以及 在一小部分问题上建立规范。 分别测量 并比较通过精神病获得的角膜阈值， 皮层诱发电位（cortical evoked potential） 探索，事后，在一个小的 年龄、性别、隐形眼镜和使用的影响，例如，的 烟草、酒精等 长期目标：建立商业潜力， 年龄/性别标准。 I期预期结果：创建安全、有效、精确、 用于测试角膜、巩膜、结膜和 眼睑躯体感觉 在一个小团体里，建立有限的年龄 和性别规范，以及样本效应，例如，隐形眼镜 和 使用烟草、酒精等物质。 技术创新和商业应用潜力： Thr现有的仪器，这将是原型， 装置，Weinstein口腔微感觉计，是一种有效的， 精确可靠的口腔感觉测试仪器。 它有可能转化为角膜 显微感觉计，这将有许多优点， 现有文书。 例如，它可以单独用于 无语言能力者皮层诱发电位的测量 （婴儿、弱智者等）在动物中也是如此。 以下 现有设备的缺点在该设备中是不可能的： 1.感染的风险，如头发或线，2。伤害 角膜，与铂丝一样，3.无法低于 阈值力，4.用可见的刺激引起恐惧。 本研究可能导致的商业应用： 制造一种销售给眼科医生，验光师， 诊所、实验室以及医学和验光学校。