DEVELOPMENT OF AN ORAL ESTHESIOMETER

口腔感觉计的开发

• 批准号: 3494770
• 负责人: SIDNEY WEINSTEIN
• 金额: $ 5万
• 依托单位: NEUROCOMMUNICATION RESEARCH LABS, INC.
• 依托单位国家: 美国
• 财政年份: 1992
• 资助国家: 美国
• 起止时间: 1992-05-10 至 1992-10-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3494770
• 关键词: biomedical equipment development; biosensor device; clinical biomedical equipment; human subject; sensory thresholds; tongue; touch

Recent research by Sidney Weinstein, Ph.D., Ronald Drozdenko, Ph.D., and Curt Weinstein, M.A., all of Pharmaceutical & Cosmetic Evaluations division NeuroCommunication Research Laboratories, Danbury, Connecticut, indicated that a tactile tongue esthesiometer could be made from an existing oral esthesiometer, trade name WOM. A pilot study indicated that the temporary mock-up of the tactile-tongue esthesiometer had high reliability and validity coefficients. Further, the device is easily sterilized without losing its calibration in comparison to the Semmes-Weinstein Pressure Esthesiometer (a device much used in the field). The technical objectives for Phase I are: 1. to create the device; 2. to demonstrate practicality by calibration of the stimulus; 3. to check reliability of the stimulus; 4. to check reliability of thresholds; and 5. to apply for patent protection. In Phase II, indices of validity will be measured and norms established. The device can be used as requested (NIDCD SBIR-I Topic 25. Touch. Section C: Design and development of tactile devices to measure sensitivity of the tongue.), and can be used to assess irritation as reflected in heightened tactile thresholds (Weinstein, C, Drozdenko, R. Weinstein, S, 1988. Evidence supporting a new model for the evaluation of skin irritation. Journal Society of Cosmetic Chemists).

西德尼·温斯坦博士、罗纳德·德罗兹登科博士和 Curt Weinstein，医学硕士，所有药品和化妆品评估部 康涅狄格州丹伯里的神经通讯研究实验室表示 触觉舌头感受器可以从现有的口腔 感官测定仪，商标为WOM。一项试点研究表明，临时 触觉舌感觉仪样机具有较高的可靠性和可信度 效度系数。此外，该设备很容易在没有消毒的情况下被消毒 与塞姆斯-温斯坦压强相比失去定标 评价仪(在现场经常使用的一种仪器)。 第一阶段的技术目标是：1.制造设备；2. 通过对刺激进行校准来证明其实用性；3.检查 刺激的可靠性；4.检查阈值的可靠性；5. 申请专利保护。在第二阶段，效度指数将为 衡量并建立规范。该设备可以根据要求使用(NIDCD SBIR-I主题25。触碰。第三部分：触觉的设计与发展 用于测量舌头敏感度的设备。)，并可用于评估 触觉阈值升高所反映的刺激(Weinstein，C， 卓兹登科，R·韦恩斯坦，S，1988。支持一种新模式的证据 皮肤刺激性的评估。化妆品化学家学会杂志)。