Additive manufacturing of advanced medical devices for cartilage regeneration: minimally invasive early intervention

用于软骨再生的先进医疗器械的增材制造：微创早期干预

• 批准号: EP/N025059/1
• 负责人: Julian Jones
• 金额: $ 134.7万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FN025059%2F1
• 关键词: Additive; manufacturing; advanced; medical; devices

No current surgical technique can regenerate articular cartilage and no current device can mimic the properties of cartilage. This Partnership will accelerate delivery of an innovative medical device for healing cartilage that will cross a frontier in orthopaedic surgery, allowing regeneration of articular cartilage rather than replacement. The device will restore cartilage to its healthy state. The surgical technique will be optimised through a new precise and minimally invasive keyhole technique. Patients will be able to use their knee immediately after the operation and recovery time will be rapid. Osteoarthritis affects 1 in 4 people, is debilitating and costs >£3bn in UK lost economic productivity, >£2.4bn in out-of-work benefits and contributes to the NHS's £5.4bn annual spend on musculoskeletal disorders. Current treatment for severe osteoarthritis is total joint replacement and current best practice for cartilage impact damage is microfracture, which involves drilling into bone to liberate the marrow, which can form weak fibrous cartilage over the defect. Early intervention is important as complete degeneration results in total joint replacement. The problem is that the cartilage only lasts 2-5 years before the procedure must be repeated and total joint replacements are major operations, which involve removing a lot of tissue, and last 15-25 years. Previous EPSRC research grants by Jones led to the invention of a new type of material that produced unique properties in terms of strength, flexibility and biodegradation. In fact, the mechanical properties can be precisely selected to match cartilage or bone. The material can also self heal. When 3-D printed, the material is able to instruct cartilage cells to produce articular cartilage rather than fibrous cartilage. Imperial Innovations submitted a patent, providing a strong IP position. Our Healthcare Impact Partnership will bring expertise in biomechanics, precision surgery, medical device manufacture, technology transfer and regulatory procedures and product delivery. The team will evaluate the device and develop manufacturing capability, producing cost-effective, reliable and effective medical devices. Surgery will be tested in cadaver knees for how they fit and ensure they can provide an immediate articular surface. Then, biological testing will determine whether our hypothesis that the device can guide the regeneration of the cartilage under joint loading. Eventually, surgeons will be able to send implant design specifications to the medical device company and receive a bespoke, patient specific device within a few days.

目前没有一种外科技术可以再生关节软骨，也没有一种现有的设备可以模拟软骨的特性。这一合作伙伴关系将加快提供一种治疗软骨的创新医疗设备，这种设备将跨越矫形外科的前沿，允许关节软骨再生而不是替换。该设备将使软骨恢复到其健康状态。通过一种新的精确和微创的锁孔技术，手术技术将得到优化。患者将能够在手术后立即使用膝盖，恢复时间将会很快。骨关节炎影响着每4个人中的1个人，使人虚弱，并使英国损失30亿英镑的经济生产力，24亿英镑的失业救济金，以及英国国民医疗服务体系每年54亿英镑的肌肉骨骼疾病支出。目前治疗严重骨关节炎的方法是全关节置换术，目前软骨冲击性损伤的最佳治疗方法是微骨折，即钻入骨中释放骨髓，在缺损处形成脆弱的纤维软骨。早期干预很重要，因为完全退变会导致关节完全置换。问题是，在必须重复手术之前，软骨只持续2-5年，而全关节置换是涉及大量组织切除的主要手术，持续15-25年。琼斯之前的EPSRC研究拨款导致了一种新型材料的发明，这种材料在强度、灵活性和生物降解性方面具有独特的性能。事实上，机械性能可以精确地选择以匹配软骨或骨骼。这种材料也可以自我愈合。当3D打印时，该材料能够指示软骨细胞产生关节软骨，而不是纤维软骨。帝国创新提交了一项专利，提供了强有力的知识产权地位。我们的医疗影响伙伴关系将带来生物力学、精密手术、医疗器械制造、技术转让和监管程序以及产品交付方面的专业知识。该团队将评估该设备并开发制造能力，生产具有成本效益、可靠和有效的医疗设备。手术将在身体膝盖上进行测试，以确定它们的适合性，并确保它们能够立即提供关节表面。然后，生物测试将确定我们的假设，即该设备是否可以在关节负荷下引导软骨再生。最终，外科医生将能够将植入物设计规范发送给医疗设备公司，并在几天内收到定制的、针对患者的设备。

项目成果

Exploratory Full-Field Mechanical Analysis across the Osteochondral Tissue-Biomaterial Interface in an Ovine Model.

• DOI: 10.3390/ma13183911
• 发表时间: 2020-09-04
• 期刊: Materials (Basel, Switzerland)
• 作者: Clark JN;Heyraud A;Tavana S;Al-Jabri T;Tallia F;Clark B;Blunn GW;Cobb JP;Hansen U;Jones JR;Jeffers JRT
• 通讯作者: Jeffers JRT

Can metabolic profiling provide a new description of osteoarthritis and enable a personalised medicine approach?

• DOI: 10.1007/s10067-020-05106-3
• 发表时间: 2020-12
• 期刊: Clinical rheumatology
• 影响因子: 3.4
• 作者: Jaggard MKJ;Boulangé CL;Graça G;Vaghela U;Akhbari P;Bhattacharya R;Williams HRT;Lindon JC;Gupte CM
• 通讯作者: Gupte CM

Quantifying 3D Strain in Scaffold Implants for Regenerative Medicine.

• DOI: 10.3390/ma13173890
• 发表时间: 2020-09-03
• 期刊: Materials (Basel, Switzerland)
• 作者: Clark JN;Tavana S;Heyraud A;Tallia F;Jones JR;Hansen U;Jeffers JRT
• 通讯作者: Jeffers JRT