Biodegradable hybrid screws for ligament-bone interface regeneration

用于韧带-骨界面再生的可生物降解混合螺钉

• 批准号: EP/S025782/1
• 负责人: Julian Jones
• 金额: $ 142.71万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2019
• 资助国家: 英国
• 起止时间: 2019 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FS025782%2F1
• 关键词: Biodegradable; hybrid; screws; ligament; bone

Anterior Cruciate Ligament injuries are often in the news as they are potentially career ending for footballers and athletes. One of the well-known incidents was seen during 2006 World Cup match between England and Sweden, where Michael Owen ruptured his ACL. This is not just a problem for elite athletes. Approximately 20,000 people in the UK need ACL repair every year and the National Health Service (NHS) performs about 11,000 ACL reconstruction surgeries per year.Reconstructive surgery of the ACL usually involves harvesting replacement ACL graft from the patient's own hamstring tendons. The damaged ACL is removed through arthroscopy (keyhole surgery), then tunnels are drilled in femur (thigh bone) and tibia (shin bone) in the knee joint area. The replacement graft is aligned/positioned through the tunnels, and opposite ends are fixated in the tibial bone tunnel by interference screws. Our clinicians and our medical device partner Xiros have identified an unmet clinical need for new screws and ACL reconstruction devices. Current metallic screws will be eventually rejected by the body as they are bioinert and will undergo fibrous encapsulation, but they can also tear the graft. The aim here is to develop an ideal screw that would be bioactive, to stimulate bonding to bone and regeneration of the connective tissue/ bone interface and biodegradable integrating the graft into the bone. The screw must also be strong, tough and a certain stiffness. Biodegradable polymer/bioactive ceramic composite screws exist, but they often fail and need replacing. This is because the bioactive component is buried in the polymer and the degradation rate of the polymer is uncontrolled and can be catastrophic or cause cysts. Our hybrid screws will overcome those problems, giving strength and a specifically designed biodegradation rate to match the rate of restoration of the bone/connective tissue interface. In some cases, it is not the screw that fails, but the tendon graft, therefore we will also develop a new totally synthetic device that eliminates the need for harvesting from the hamstring and provides more reliable long term performance, while integrating with the host bone.

前十字韧带损伤经常出现在新闻中，因为这可能会导致足球运动员和运动员的职业生涯结束。其中一个著名的事件发生在2006年世界杯英格兰对瑞典的比赛中，迈克尔·欧文的前交叉韧带断裂。这不仅仅是精英运动员的问题。在英国，每年大约有2万人需要前交叉韧带修复，国家卫生服务（NHS）每年进行大约1.1万例前交叉韧带重建手术。前交叉韧带的重建手术通常包括从患者自己的腘绳肌腱中获取替代前交叉韧带移植物。通过关节镜（锁眼手术）切除受损的前交叉韧带，然后在膝关节区域的股骨（大腿骨）和胫骨（胫骨）上钻隧道。置换移植物通过隧道对齐/定位，并通过干涉螺钉将其两端固定在胫骨隧道中。我们的临床医生和我们的医疗设备合作伙伴Xiros已经确定了对新螺钉和ACL重建设备的未满足的临床需求。目前的金属螺钉最终会被身体排斥，因为它们是生物惰性的，并且会被纤维包裹，但它们也会撕裂移植物。我们的目标是开发一种理想的具有生物活性的螺钉，能够刺激与骨的结合，促进结缔组织/骨界面的再生，并将移植物整合到骨中。螺杆还必须坚固、坚韧并具有一定的刚度。生物可降解聚合物/生物活性陶瓷复合螺钉已经存在，但它们经常失效，需要更换。这是因为生物活性成分被埋在聚合物中，聚合物的降解速度是不受控制的，可能是灾难性的或导致囊肿。我们的混合螺钉将克服这些问题，提供强度和专门设计的生物降解率，以匹配骨/结缔组织界面的恢复速度。在某些情况下，不是螺钉失效，而是肌腱移植物失效，因此我们还将开发一种新的完全合成的装置，消除了从腘绳肌获取的需要，提供更可靠的长期性能，同时与宿主骨结合。

项目成果

3D printed hybrid for articular cartilage regeneration: from design to

用于关节软骨再生的 3D 打印混合体：从设计到

• 发表时间: 2023
• 期刊: TISSUE ENGINEERING PART A
• 影响因子: 4.1
• 作者: Tallia Francesca

Training Surgeons to Perform Arthroscopic All-Inside Meniscal Repair: A Randomized Controlled Trial Evaluating the Effectiveness of a Novel Cognitive Task Analysis Teaching Tool, Imperial College London/University College London Meniscus Repair Cognitive Task Analysis (IUMeRCTA).

• DOI: 10.1177/03635465211021652
• 发表时间: 2021-07
• 期刊: The American journal of sports medicine
• 作者: Karamchandani U;Bhattacharyya R;Patel R;Oussedik S;Bhattacharya R;Gupte C
• 通讯作者: Gupte C

3D Printed Porous Methacrylate/Silica Hybrid Scaffold for Bone Substitution.

• DOI: 10.1002/adhm.202100117
• 发表时间: 2021-06
• 期刊: Advanced healthcare materials
• 影响因子: 10
• 作者: Chung JJ;Yoo J;Sum BST;Li S;Lee S;Kim TH;Li Z;Stevens MM;Georgiou TK;Jung Y;Jones JR
• 通讯作者: Jones JR

Differences between infected and noninfected synovial fluid.

• DOI: 10.1302/2046-3758.101.bjr-2020-0285.r1
• 发表时间: 2021-01
• 期刊: Bone & joint research
• 影响因子: 4.6
• 作者: Akhbari P;Jaggard MK;Boulangé CL;Vaghela U;Graça G;Bhattacharya R;Lindon JC;Williams HRT;Gupte CM
• 通讯作者: Gupte CM

Ovine Mesenchymal Stem Cell Chondrogenesis on a Novel 3D-Printed Hybrid Scaffold In Vitro

• DOI: 10.3390/bioengineering11020112
• 发表时间: 2024-02-01
• 期刊: BIOENGINEERING-BASEL
• 影响因子: 4.6
• 作者: De Mori，Arianna;Heyraud，Agathe;Al-Jabri，Talal
• 通讯作者: Al-Jabri，Talal